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New Cancer Gene Therapy Study Findings Have Been Reported from Jilin University (Knockdown of hTERT by siRNA inhibits cervical cancer cell growth in...

August 25, 2014



New Cancer Gene Therapy Study Findings Have Been Reported from Jilin University (Knockdown of hTERT by siRNA inhibits cervical cancer cell growth in vitro and in vivo)

By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Investigators publish new report on Biotechnology. According to news reporting originating in Changchun, People's Republic of China, by NewsRx journalists, research stated, "Human telomerase reverse transcriptase (hTERT) is the catalytic component of telomerase that facilitates tumor cell invasion and proliferation. It has been reported that telomerase and hTERT are significantly upregulated in majority of cancers including cervical cancer, thus, downregulation of hTERT is a promising target in malignant tumor treatment."

The news reporters obtained a quote from the research from Jilin University, "We established a short interfering RNA (siRNA) targeting hTERT, and transfected it into HeLa cells (a cervical cancer cell line) to investigate the effect of cell proliferation, apoptosis, migration and invasion in cervical cancer cells. The results showed that siRNA targeting hTERT could effectively knock down hTERT expression, remarkably suppress telomerase activity, cell proliferation, migration and invasion, and induced cell apoptosis of cervical cancers cells in vitro. In addition, we evaluated whether siRNA targeting hTERT affects tumor growth in nude mice, and found that it dramatically inhibited tumorigenesis and growth of mice injected with siRNA targeting hTERT. Furthermore, we also found that knockdown of hTERT was able to significantly suppress constitutive phosphorylation of Akt, PI3K, which might imply that reduction of hTERT inhibited tumor growth via the PI3K/Akt signaling pathway to some extent."

According to the news reporters, the research concluded: "These results suggest that the suppression of hTERT expression by siRNA inhibits cervical cancer cell growth in vitro and in vivo, and may provide a novel target for anticancer gene therapy."

For more information on this research see: Knockdown of hTERT by siRNA inhibits cervical cancer cell growth in vitro and in vivo. International Journal of Oncology, 2014;45(3):1216-1224. International Journal of Oncology can be contacted at: Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece (see also Biotechnology).

Our news correspondents report that additional information may be obtained by contacting Y.A. Shi, Jilin University, Norman Bethune Coll Med Sci, Changchun 130021, People's Republic of China. Additional authors for this research include Q. Zhao, L.H. Zhang, W. Du, X.Y. Wang, X. He, S. Wu and Y.L. Li.

Keywords for this news article include: Asia, Biotechnology, siRNA, Genetics, Oncology, Changchun, Telomerase, Carrier Proteins, Cell Proliferation, Ribonucleoproteins, Cancer Gene Therapy, Phosphotransferases, Small Interference RNAs, People's Republic of China, DNA Nucleotidyltransferases, RNA-Directed DNA Polymerase

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Gene Therapy Week


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