Findings on Proteomics Discussed by Investigators at Shaheed Beheshti University of Medical Sciences (Triangular gold nanoparticles conjugated with peptide ligands: A new class of inhibitor for Candida albicans secreted aspartyl proteinase)
By a News Reporter-Staff News Editor at Drug Week -- Current study results on Proteomics have been published. According to news reporting originating from Tehran, Iran, by NewsRx correspondents, research stated, "The aim of this study was to find the peptide ligands to inhibit Candida albicans secreted aspartyl proteinase 2 (Sap2). First, a ligand library, containing 300 different peptides, was constructed, and their interaction with Sap2 was separately calculated by molecular dynamic software."
Our news editors obtained a quote from the research from the Shaheed Beheshti University of Medical Sciences, "Second, 10 peptide ligands with the lowest intermolecular energy were selected. Then, triangular gold nanoparticles were synthesized, and separately conjugated with the peptide ligands. After synthesis, antifungal property and Sap inactivation of conjugated triangular gold nanoparticles, peptide ligands, and naked triangular gold nanoparticle were separately assessed, against thirty clinical isolates of C. albicans. in this study, we measured the uptake of conjugated and naked nanoparticles by atomic adsorption spectroscopy. This study showed that naked triangular gold nanoparticle and all conjugated triangular gold nanoparticles had high antifungal activity, but no peptide ligands had such activity. Of 300 peptide ligands, the peptide containing N-Cys-Lys-Lys-Arg-Met-Met-Lys-Ser-Met-Cys-C and its conjugate had the highest capability to inhibit Sap."
According to the news editors, the research concluded: "Moreover, the uptake assay demonstrated that triangular gold nanoparticles conjugated with the peptide ligand had the highest uptake."
For more information on this research see: Triangular gold nanoparticles conjugated with peptide ligands: A new class of inhibitor for Candida albicans secreted aspartyl proteinase. Biochemical Pharmacology, 2014;90(4):349-355. Biochemical Pharmacology can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Biochemical Pharmacology - www.elsevier.com/wps/product/cws_home/525454)
The news editors report that additional information may be obtained by contacting A. Jebali, Shahid Beheshti Univ Med Sci, Sch Med, Dept. of Pharmacol, Tehran, Iran. Additional authors for this research include F.H.E. Hajjar, S. Hekmatimoghaddam, B. Kazemi, J.M. De La Fuente and M. Rashidi (see also Proteomics).
Keywords for this news article include: Iran, Asia, Tehran, Peptides, Proteins, Proteomics, Nanotechnology, Gold Nanoparticles, Emerging Technologies
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