Findings on Nanofibers Detailed by Investigators at Weizmann Institute of Science (Thermodynamic Factors Impacting the Peptide-Driven Self-Assembly of Perylene Diimide Nanofibers)
By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Nanofibers. According to news originating from Rehovot, Israel, by NewsRx correspondents, research stated, "Synthetic peptides offer enormous potential to encode the assembly of molecular electronic components, provided that the complex range of interactions is distilled into simple design rules. Here, we report a spectroscopic investigation of aggregation in an extensive series of peptide-perylene diiimide conjugates designed to interrogate the effect of structural variations."
Our news journalists obtained a quote from the research from the Weizmann Institute of Science, "By fitting different contributions to temperature dependent optical absorption spectra, we quantify both the thermodynamics and the nature of aggregation for peptides by incrementally varying hydrophobicity, charge density, length, as well as asymmetric substitution with a hexyl chain, and stereocenter inversion. We find that coarse effects like hydrophobicity and hexyl substitution have the greatest impact on aggregation thermodynamics, which are separated into enthalpic and entropic contributions. Moreover, significant peptide packing effects are resolved via stereocenter inversion studies, particularly when examining the nature of aggregates formed and the coupling between it electronic orbitals."
According to the news editors, the research concluded: "Our results develop a quantitative framework for establishing structure function relationships that will underpin the design of self-assembling peptide electronic materials."
For more information on this research see: Thermodynamic Factors Impacting the Peptide-Driven Self-Assembly of Perylene Diimide Nanofibers. Journal of Physical Chemistry B, 2014;118(29):8642-8651. Journal of Physical Chemistry B can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of Physical Chemistry B - www.pubs.acs.org/journal/jpcbfk)
The news correspondents report that additional information may be obtained from G.L. Eakins, Weizmann Inst Sci, Dept. of Organ Chem, IL-76100 Rehovot, Israel. Additional authors for this research include J.K. Gallaher, R.A. Keyzers, A. Falber, J.E.A. Webb, A. Laos, Y. Tidhar, H. Weissman, B. Rybtchinski, P. Thordarson and J.M. Hodgkiss (see also Nanofibers).
Keywords for this news article include: Asia, Israel, Rehovot, Physics, Nanotechnology, Thermodynamics, Emerging Technologies
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