Findings from Tel Aviv University Has Provided New Data on Essential Amino Acids [Seamless Metallic Coating and Surface Adhesion of Self-Assembled Bioinspired Nanostructures Based on Di-(3,4-dihydroxy-L-phenylalanine) Peptide Motif]
By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Essential Amino Acids have been published. According to news reporting originating from Tel Aviv, Israel, by NewsRx correspondents, research stated, "The noncoded aromatic 3,4-dihydroxy-L-phenylalanine (DOPA) amino add has a pivotal role in the remarkable adhesive properties displayed by marine mussels. These properties have inspired the design of adhesive chemical entities through various synthetic approaches."
Our news editors obtained a quote from the research from Tel Aviv University, "DOPA-containing bioinspired polymers have a broad functional appeal beyond adhesion due to the diverse chemical interactions presented by the catechol moieties. Here, we harnessed the molecular self-assembly abilities of very short peptide motifs to develop analogous DOPA-containing supramolecular polymers. The DOPA-containing DOPA-DOPA and Fmoc-DOPA-DOPA building blocks were designed by substituting the phenylalanines in the well-studied diphenylalanine self-assembling motif and its 9-fluorenylmethoxycarbonyl (Fmoc)-protected derivative. These peptides self-organized into fibrillar nanoassemblies, displaying high density of catechol functional groups. Furthermore, the Fmoc-DOPA-DOPA peptide was found to act as a low molecular weight hydrogelator, forming self-supporting hydrogel which was rheologically characterized. We studied these assemblies using electron microscopy and explored their applicative potential by examining their ability to spontaneously reduce metal cations into elementary metal. By applying Ionic silver to the hydrogel, we observed efficient reduction into silver nanoparticles and the remarkable seamless metallic coating of the assemblies. Similar redox abilities were observed with the DOPA-DOPA assemblies. In an effort to impart adhesiveness to the obtained assemblies, we incorporated lysine (Lys) into the Fmoc-DOPA-DOPA building block. The assemblies of Fmoc-DOPA-DOPA-Lys were capable of gluing together glass surfaces, and their adhesion properties were investigated using atomic force microscopy. Taken together, a class of DOPA-containing self-assembling peptides was designed."
According to the news editors, the research concluded: "These nanoassemblies display unique properties and can serve as multifunctional platforms for various biotechnological applications."
For more information on this research see: Seamless Metallic Coating and Surface Adhesion of Self-Assembled Bioinspired Nanostructures Based on Di-(3,4-dihydroxy-L-phenylalanine) Peptide Motif. ACS Nano, 2014;8(7):7220-7228. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)
The news editors report that additional information may be obtained by contacting G. Fichman, Tel Aviv University, Iby & Aladar Fleischman Fac Engn, Dept. of Mat Sci & Engn, IL-6997801 Tel Aviv, Israel. Additional authors for this research include L. Adler-Abramovich, S. Manohar, I. Mironi-Harpaz, T. Guterman, D. Seliktar, P.B. Messersmith and E. Gazit (see also Essential Amino Acids).
Keywords for this news article include: Asia, Israel, Tel Aviv, Phenylalanine, Nanoassemblies, Nanostructural, Nanostructures, Nanotechnology, Aromatic Amino Acids, Emerging Technologies, Essential Amino Acids
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