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Data on Zoo and Wildlife Medicine Detailed by Researchers at Marine Mammal Center [Pharmacokinetics Of Ceftiofur Crystalline-free Acid (excede...

August 26, 2014



Data on Zoo and Wildlife Medicine Detailed by Researchers at Marine Mammal Center [Pharmacokinetics Of Ceftiofur Crystalline-free Acid (excede Sterile Suspension (r)) Administered Via Intramuscular Injection In Wild California Sea Lions ...]

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Life Science Research have been published. According to news reporting originating in Sausalito, California, by NewsRx journalists, research stated, "The pharmacokinetics of ceftiofur crystalline-free acid (EXCEDE Sterile Suspension, 200 mg ceftiofur equivalents/ml) were determined for the California sea lion (Zalophus californianus). A single dose of EXCEDE was administered intramuscularly at 6.6 mg/kg to 12 wild California sea lions during rehabilitation."

The news reporters obtained a quote from the research from Marine Mammal Center, "The first 10 animals were each assigned to two blood collection time points, with a total of 10 time points at: 6, 12, 24, 48, 72, 96, 120, 144, 168, and 192 hr after administration of the drug. An additional two animals were sampled 1, 2, 3, 4, 5, and 6 hr postinjection. Plasma was separated within 10 min of blood collection and stored at -20 degrees C until analysis. Plasma concentrations of ceftiofur, desfuroylceftiofur, and related metabolites, were determined using liquid chromatography with tandem mass spectrometry (MS). Maximum plasma concentrations of ceftiofur and related metabolites were observed 24 hr postdosing with a mean concentration of 3.6 lg/ml. The half life (60 hr) and area under the curve (270 mu g.hr/ml) were also determined."

According to the news reporters, the research concluded: "These data indicate that a single dose of EXCEDE at 6.6 mg/kg i.m. would likely maintain a mean plasma drug level >0.6 mu g/ml for 5 days and.0.5 mu g/ml for 8 days."

For more information on this research see: Pharmacokinetics Of Ceftiofur Crystalline-free Acid (excede Sterile Suspension (r)) Administered Via Intramuscular Injection In Wild California Sea Lions (zalophus Californianus). Journal of Zoo and Wildlife Medicine, 2013;44(3):714-720. Journal of Zoo and Wildlife Medicine can be contacted at: Amer Assoc Zoo Veterinarians, 581705 White Oak Road, Yulee, FL 32097, USA (see also Life Science Research).

Our news correspondents report that additional information may be obtained by contacting J. Meegan, Marine Mammal Center, Sausalito, CA 94965, United States. Additional authors for this research include W.T. Collard, G.S. Grover, N. Pussini, W.G. Van Bonn and F.M.D. Gulland.

Keywords for this news article include: Sausalito, California, United States, Life Science Research, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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