Data on Cancer Therapy Reported by Researchers at Kyung Hee University (Tumor-specific delivery of siRNA using supramolecular assembly of hyaluronic acid nanoparticles and 2b RNA-binding protein/siRNA complexes)
By a News Reporter-Staff News Editor at Drug Week -- Current study results on Oncology have been published. According to news reporting originating from Seoul, South Korea, by NewsRx correspondents, research stated, "Anticancer therapeutics delivering exogenous siRNA have been explored to suppress the tumor-associated genes, but several limitations of siRNA delivery such as tumor-targeted delivery, controlled siRNA release at the sites of interest, or instabilities of siRNA in physiological fluids should be preferentially addressed for its clinical applications. As an attempt to meet these criteria, we designed a supramolecular assembly, which was composed of cholesterol-bearing hyaluronic acid (HA-Chol) conjugates and 2b RNA-binding protein (2b)/siRNA complexes."
Our news editors obtained a quote from the research from Kyung Hee University, "In contrast to the traditional siRNA polyplexes using electrostatic interactions, HA-Chol nanoparticles, as a results of self-assembly of HA-Chol conjugates, provide the hydrophobic core that acts as the container for 2b protein/siRNA complexes, where a high affinity of 2b protein for siRNA could neutralize the negative-charged siRNA. Here, we investigated the potential of HA-Chol/2b/siRNA complexes as the siRNA carriers that provide encapsulation, protection, and targeted delivery of siRNA. The HA-Chol nanoparticles could selectively deliver 2b protein/siRNA complexes to the tumor cells with up-regulated CD44 receptors and suppress the expression of target gene. The pH-associated binding properties of siRNA for 2b proteins allowed the controlled release of siRNA in the endocytic compartments, and ultimately the released siRNA could obtain the RNAi acitivities in the cells, whereas the encapsulated 2b proteins still stayed within the HA-Chol nanoparticles."
According to the news editors, the research concluded: "Our delivery systems demonstrate the promising potential of the efficient siRNA carriers in the anticancer therapeutic applications."
For more information on this research see: Tumor-specific delivery of siRNA using supramolecular assembly of hyaluronic acid nanoparticles and 2b RNA-binding protein/siRNA complexes. Biomaterials, 2014;35(25):7121-32. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
The news editors report that additional information may be obtained by contacting K.M. Choi, Institute of Global Environment and Dept. of Biology, Kyung Hee University, Dongdaemun-Gu, Seoul 130-701, South Korea. Additional authors for this research include M. Jang, J.H. Kim and H.J Ahn (see also Oncology).
Keywords for this news article include: Asia, Seoul, Therapy, Oncology, South Korea, Nanoparticle, Nanotechnology, Nucleoproteins, Carrier Proteins, RNA Binding Proteins, Emerging Technologies, Supramolecular Assemblies.
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