Iranians develop hydrogen peroxide biosensor
Heart failure increases concentration of hydrogen peroxide in tissues, which damages the inner lining of the artery called endothelium and raises the possibility of blood clot creation and heart and brain strokes. Thus, concentration of hydrogen peroxide in body fluids such as plasma gains importance.
The mortality rate by cardiovascular diseases has been on the rise, which calls for an easy, rapid and efficient method for determining the hydrogen peroxide concentration to prevent any damage to heart and brain,
The research helped develop an electrochemical biosensor made of magnetic iron oxide nanoparticles and polyfuran, which is capable of measuring hydrogen peroxide concentrations in biofluids and tissues. The research also removed minor disadvantages such as lower conductivity and thermal stability of polyfuran.
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"The component is a highly strong oxidation factor, which produces free radicals and metals in troposphere. Thus, the concentration of hydrogen peroxide in rainwater is an indication of toxicity, solubility, biocompatibility and a relative amount of metallic elements in rainwater," he said.
"The surface hydroxyl groups attached to iron oxide nanoparticles not only improve magnetic property and conductivity of nanocomposite, but also create better compatibility with furan rings to increase the surface-to-volume ratio necessary for biological applications."
The materials used in nanocomposites are cheap, biocompatible and could directly enter body tissues.
The research investigated antioxidant properties of the nanocomposite and applications in biosensors for the first time.
"A comparison of findings in this research with laboratory models indicated that using ultrasound waves in the nanocomposites improved conductivity, magnetic property, thermal stability and antioxidant properties. These properties are directly related to the minute size of particles that would be improved through optimized conditions," he said.
Baqayeri noted that the research group was currently working on developing a new generation of electrochemical biosensors to improve applied properties of nanocomposites.
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