Studies from University of Tokyo Provide New Data on Anions (Fine-Tuning of Charge-Conversion Polymer Structure for Efficient Endosomal Escape of siRNA-Loaded Calcium Phosphate Hybrid Micelles)
By a News Reporter-Staff News Editor at Science Letter -- Researchers detail new data in Anions. According to news originating from Tokyo, Japan, by NewsRx correspondents, research stated, "For efficient delivery of siRNA into the cytoplasm, a smart block copolymer of poly(ethylene glycol) and charge-conversion polymer (PEG-CCP) is developed by introducing 2-propionic-3-methylmaleic (PMM) amide as an anionic protective group into side chains of an endosome-disrupting cationic polyaspartamide derivative. The PMM amide moiety is highly susceptible to acid hydrolysis, generating the parent cationic polyaspartamide derivative at endosomal acidic pH 5.5 more rapidly than a previously synthesized cis-aconitic (ACO) amide control."
Our news journalists obtained a quote from the research from the University of Tokyo, "The PMM-based polymer is successfully integrated into a calcium phosphate (CaP) nanoparticle with siRNA, constructing PEGylated hybrid micelles (PMM micelles) having a sub-100 nm size at extracellular neutral pH 7.4. Ultimately, PMM micelles achieve the significantly higher gene silencing efficiency in cultured cancer cells, compared to ACO control micelles, probably due to the efficient endosomal escape of the PMM micelles."
According to the news editors, the research concluded: "Thus, it is demonstrated that fine-tuning of acid-labile structures in CCP improves the delivery performance of siRNA-loaded nanocarriers."
For more information on this research see: Fine-Tuning of Charge-Conversion Polymer Structure for Efficient Endosomal Escape of siRNA-Loaded Calcium Phosphate Hybrid Micelles. Macromolecular Rapid Communications, 2014;35(13):1211-1215. Macromolecular Rapid Communications can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Macromolecular Rapid Communications - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-3927)
The news correspondents report that additional information may be obtained from Y. Maeda, University of Tokyo, Grad Sch Engn, Dept. of Mat Engn, Bunkyo Ku, Tokyo 1138656, Japan. Additional authors for this research include F. Pittella, T. Nomoto, H. Takemoto, N. Nishiyama, K. Miyata and K. Kataoka (see also Anions).
Keywords for this news article include: Asia, Tokyo, Japan, Anions, Phosphoric Acids, Calcium Compounds, Calcium Phosphates, Inorganic Chemicals, Phosphorus Compounds
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