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Researchers at School of Medicine Target Stem Cells (Bone-Like Mineral Nucleating Peptide Nanofibers Induce Differentiation of Human Mesenchymal Stem...

August 22, 2014



Researchers at School of Medicine Target Stem Cells (Bone-Like Mineral Nucleating Peptide Nanofibers Induce Differentiation of Human Mesenchymal Stem Cells into Mature Osteoblasts)

By a News Reporter-Staff News Editor at Science Letter -- Data detailed on Stem Cell Research have been presented. According to news reporting from Ankara, Turkey, by NewsRx journalists, research stated, "A bone implant should integrate to the tissue through a bone-like mineralized interface, which requires increased osteoblast activity at the implant tissue boundary. Modification of the implant surface with synthetic bioinstructive cues facilitates on-site differentiation of progenitor stem cells to functional mature osteoblasts and results in subsequent mineralization."

The news correspondents obtained a quote from the research from the School of Medicine, "Inspired by the bioactive domains of the bone extracellular matrix proteins and the mussel adhesive proteins, we synthesized peptide nanofibers to promote bone-like mineralization on the implant surface. Nanofibers functionalized with osteoinductive collagen I derived Asp-Gly-Glu-Ala (DGEA) peptide sequence provide an advantage in initial adhesion, spreading, and early commitment to osteogenic differentiation for mesenchymal stem cells (hMSCs). In this study, we demonstrated that this early osteogenic commitment, however, does not necessarily guarantee a priority for maturation into functional osteoblasts. Similar to natural biological cascades, early commitment should be further supported with additional signals to provide a long-term effect on differentiation. Here, we showed that peptide nanofibers functionalized with Glu-Glu-Glu (EEE) sequence enhanced mineralization abilities due to osteoinductive properties for late-stage differentiation of hMSCs. Mussel-inspired functionalization not only enables robust immobilization on metal surfaces, but also improves bone-like mineralization under physiologically simulated conditions."

According to the news reporters, the research concluded: "The multifunctional osteoinductive peptide nanofiber biointerfaces presented here facilitate osseointegration for long-term clinical stability."

For more information on this research see: Bone-Like Mineral Nucleating Peptide Nanofibers Induce Differentiation of Human Mesenchymal Stem Cells into Mature Osteoblasts. Biomacromolecules, 2014;15(7):2407-2418. Biomacromolecules can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Biomacromolecules - www.pubs.acs.org/journal/bomaf6)

Our news journalists report that additional information may be obtained by contacting H. Ceylan, Turgut Ozal Univ, Sch Med Hosp, Dept. of Hematol, TR-06510 Ankara, Turkey. Additional authors for this research include S. Kocabey, H.U. Gulsuner, O.S. Balcik, M.O. Guler and A.B. Tekinay (see also Stem Cell Research).

Keywords for this news article include: Ankara, Turkey, Eurasia, Peptides, Proteins, Nanofiber, Proteomics, Osteoblasts, Bone Research, Nanotechnology, Stem Cell Research, Emerging Technologies, Mesenchymal Stem Cells, Connective Tissue Cells

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Science Letter


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