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Recent Findings from University of Sevilla Advance Knowledge in Science (Osteoconductive potential of barrier nanoSiO2 PLGA membranes functionalized...

August 22, 2014



Recent Findings from University of Sevilla Advance Knowledge in Science (Osteoconductive potential of barrier nanoSiO2 PLGA membranes functionalized by plasma enhanced chemical vapour deposition)

By a News Reporter-Staff News Editor at Science Letter -- New research on Science is the subject of a report. According to news reporting originating from Seville, Spain, by NewsRx correspondents, research stated, "The possibility of tailoring membrane surfaces with osteoconductive potential, in particular in biodegradable devices, to create modified biomaterials that stimulate osteoblast response should make them more suitable for clinical use, hopefully enhancing bone regeneration. Bioactive inorganic materials, such as silica, have been suggested to improve the bioactivity of synthetic biopolymers."

Our news editors obtained a quote from the research from the University of Sevilla, "An in vitro study on HOB human osteoblasts was performed to assess biocompatibility and bioactivity of SiO2 functionalized poly(lactide-co-glycolide) (PLGA) membranes, prior to clinical use. A 15 nm SiO2 layer was deposited by plasma enhanced chemical vapour deposition (PECVD), onto a resorbable PLGA membrane. Samples were characterized by X-ray photoelectron spectroscopy, atomic force microscopy, scanning electron microscopy, and infrared spectroscopy (FT-IR). HOB cells were seeded on sterilized test surfaces where cell morphology, spreading, actin cytoskeletal organization, and focal adhesion expression were assessed. As proved by the FT-IR analysis of samples, the deposition by PECVD of the SiO2 onto the PLGA membrane did not alter the composition and other characteristics of the organic membrane. A temporal and spatial reorganization of cytoskeleton and focal adhesions and morphological changes in response to SiO2 nanolayer were identified in our model."

According to the news editors, the research concluded: "The novedous SiO2 deposition method is compatible with the standard sterilization protocols and reveals as a valuable tool to increase bioactivity of resorbable PLGA membranes."

For more information on this research see: Osteoconductive potential of barrier nanoSiO2 PLGA membranes functionalized by plasma enhanced chemical vapour deposition. Biomed Research International, 2014;2014():253590 (see also Science).

The news editors report that additional information may be obtained by contacting A. Terriza, Nanotechnology on Surfaces Laboratory, Instituto de Ciencia de Materiales de Sevilla (CSIC), Universidad de Sevilla, Avenida Americo Vespucio 49, 41092 Seville, Spain. Additional authors for this research include J.I. Vilches-Perez, E. de la Orden, F. Yubero, J.L. Gonzalez-Caballero, A.R. Gonzalez-Elipe, J. Vilches and M. Salido.

Keywords for this news article include: Spain, Europe, Seville, Science.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Science Letter


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