Injuries, birth defects or surgery to remove a tumor can create gaps in bone. And when they occur in the head, face or jaw, these bone defects can dramatically alter a person's appearance.
Though 'autografting' is helpful in filling bone defects in the head, face or jaw, leader of the study,
Grunlan and her colleagues at
The SMP is biodegradable, so that eventually the scaffold will disappear, leaving only new bone tissue behind.
The researchers tested the SMP scaffold by seeding the polymer with human osteoblasts. After three days, the polydopamine-coated SMPs had grown about five times more osteoblasts than those without a coating. Furthermore, the osteoblasts produced more of the two proteins, runX2 and osteopontin, that are critical for new bone formation.
The team will be presenting their research at the 248th
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