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New Analytical Science Findings from Duke University Reported (Surface-enhanced Raman scattering molecular sentinel nanoprobes for viral infection...

August 22, 2014



New Analytical Science Findings from Duke University Reported (Surface-enhanced Raman scattering molecular sentinel nanoprobes for viral infection diagnostics)

By a News Reporter-Staff News Editor at Science Letter -- Investigators discuss new findings in Science. According to news reporting originating from Durham, North Carolina, by NewsRx correspondents, research stated, "In this paper, we describe a surface-enhanced Raman scattering (SERS)-based detection approach, referred to as 'molecular sentinel' (MS) plasmonic nanoprobes, to detect an RNA target related to viral infection. The MS method is essentially a label-free technique incorporating the SERS effect modulation scheme associated with silver nanoparticles and Raman dye-labeled DNA hairpin probes."

Our news editors obtained a quote from the research from Duke University, "Hybridization with target sequences opens the hairpin and spatially separates the Raman label from the silver surface thus reducing the SERS signal of the label. Herein, we have developed a MS nanoprobe to detect the human radical S-adenosyl methionine domain containing 2 (RSAD2) RNA target as a model system for method demonstration. The human RSAD2 gene has recently emerged as a novel host-response biomarker for diagnosis of respiratory infections. Our results showed that the RSAD2 MS nanoprobes exhibits high specificity and can detect as low as 1 nM target sequences."

According to the news editors, the research concluded: "With the use of a portable Raman spectrometer and total RNA samples, we have also demonstrated for the first time the potential of the MS nanoprobe technology for detection of host-response RNA biomarkers for infectious disease diagnostics."

For more information on this research see: Surface-enhanced Raman scattering molecular sentinel nanoprobes for viral infection diagnostics. Analytica Chimica Acta, 2013;786():153-8. (Elsevier - www.elsevier.com; Analytica Chimica Acta - www.elsevier.com/wps/product/cws_home/502681)

The news editors report that additional information may be obtained by contacting H.N. Wang, Dept. of Biomedical Engineering, Duke University, Durham, NC 27708, United States. Additional authors for this research include A.M. Fales, A.K. Zaas, C.W. Woods, T. Burke, G.S. Ginsburg and T. Vo-Dinh (see also Science).

Keywords for this news article include: Viral, Virus, Durham, Science, United States, North Carolina, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Science Letter


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