The researchers modified the CNTs by chemically binding them to polymer nanoparticles that held Interleukin-2, a cell signaling protein that encourages T cell growth and proliferation. Additionally, in order to mimic the body's methods for stimulating cytotoxic T cell proliferation, the scientists seeded the surfaces of the CNTs with molecules that signaled which of the patient's cells were foreign or toxic and should be attacked.
Over the span of 14 days, the number of T cells cultured on the composite nanosystem expanded by a factor of 200, according to the researchers. Also, the method required 1,000 times less Interleukin-2 than conventional culture conditions. A magnet was used to separate the CNT-polymer composites from the T cells prior to injection.
"In repressing the body's immune response, tumors are like a castle with a moat around it," says
According to Fahmy, previous procedures for boosting antigen-specific T cells required exposing the patient's harvested immune cells to other cells that stimulate activation and proliferation, a costly procedure that risks an adverse reaction to foreign cells. The
"Modulatory nanotechnologies can present unique opportunities for promising new therapies such as T cell immunotherapy," says
TNS 18DejucosGrace-140814-30FurigayJane-4828797 30FurigayJane
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OCTOBER 30, 2014
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