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Findings from French National Institute of Health and Medical Research (INSERM) Has Provided New Information about Neurons (Cell specific electrodes...

August 22, 2014



Findings from French National Institute of Health and Medical Research (INSERM) Has Provided New Information about Neurons (Cell specific electrodes for neuronal network reconstruction and monitoring)

By a News Reporter-Staff News Editor at Science Letter -- Fresh data on Neurons are presented in a new report. According to news reporting originating in Paris, France, by NewsRx journalists, research stated, "Direct interfacing of neurons with electronic devices has been investigated for both prosthetic and neuro-computing applications. In vitro neuronal networks provide great tools not only for improving neuroprostheses but also to take advantage of their computing abilities."

The news reporters obtained a quote from the research from the French National Institute of Health and Medical Research (INSERM), "However, it is often difficult to organize neuronal networks according to specific cell distributions. Our aim was to develop a cell-type specific immobilization of neurons on individual electrodes to produce organized in vitro neuronal networks on multi-electrode arrays (MEAs). We demonstrate the selective capture of retinal neurons on antibody functionalized surfaces following the formation of self-assembled monolayers from protein-thiol conjugates by simple contact and protein-polypyrrole deposits by electrochemical functionalization. This neuronal selection was achieved on gold for either cone photoreceptors or retinal ganglion neurons using a PNA lectin or a Thy1 antibody, respectively. Anti-fouling of un-functionalized gold surfaces was optimized to increase the capture efficiencies. The technique was extended to electrode arrays by addressing electropolymerization of pyrrole monomers and pyrrole-protein conjugates to active electrodes. Retinal ganglion cell recording on the array further demonstrated the integrity of these neurons following their selection on polypyrrole-coated electrodes."

According to the news reporters, the research concluded: "Therefore, this protein-polypyrrole electrodeposition could provide a new approach to generate organized in vitro neuronal networks."

For more information on this research see: Cell specific electrodes for neuronal network reconstruction and monitoring. Analyst, 2014;139(13):3281-9. (Royal Society of Chemistry - www.rsc.org/; Analyst - pubs.rsc.org/en/journals/journalissues/an)

Our news correspondents report that additional information may be obtained by contacting A. Bendali, INSERM, U968, Institut de la Vision, 17 rue Moreau, Paris, F-75012, France. Additional authors for this research include S. Bouguelia, Y. Roupioz, V. Forster, P. Mailley, R. Benosman, T. Livache, J.A. Sahel and S. Picaud (see also Neurons).

Keywords for this news article include: Paris, Cells, France, Europe, Neurons.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Science Letter


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