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Study Results from Kagoshima University Provide New Insights into Cancer Gene Therapy (Identification of tumour suppressive microRNA-451a in...

August 18, 2014



Study Results from Kagoshima University Provide New Insights into Cancer Gene Therapy (Identification of tumour suppressive microRNA-451a in hypopharyngeal squamous cell carcinoma based on microRNA expression signature)

By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Investigators discuss new findings in Biotechnology. According to news reporting from Kagoshima, Japan, by NewsRx journalists, research stated, "Hypopharyngeal squamous cell carcinoma (HSCC) has a very poor prognosis because of its high rates of regional and distant metastasis. Identification of differentially expressed miRNAs and their regulated molecular targets in tumour cells might enhance our understanding of the molecular mechanisms of metastasis in human cancers."

The news correspondents obtained a quote from the research from Kagoshima University, "A HSCC miRNA signature was constructed by array-based methods. Functional studies of microRNA-451a (miR-451a) and target genes were performed to investigate cell proliferation, migration and invasion by cancer cell lines. To identify miR-451a-regulated molecular targets, we adopted gene expression analysis and in silico database analysis. Our miRNA signature revealed that miR-451a was significantly downregulated in HSCC. Restoration of miR-451a in cancer cell lines revealed that this miRNA significantly inhibited cancer cell migration and invasion. Our data demonstrated that the gene coding for endothelial and smooth muscle cell-derived neuropilin-like molecule (ESDN/DCBLD2) was a direct target of miR-451a regulation. Silencing of ESDN inhibited cell migration and invasion by cancer cells. Loss of tumour suppressive miR-451a enhanced cancer cell migration and invasion in HSCC through direct regulation of ESDN."

According to the news reporters, the research concluded: "Our miRNA signature and functional analysis of targets regulated by tumour suppressive miR-451a provide new insights into the potential mechanisms of HSCC oncogenesis and metastasis."

For more information on this research see: Identification of tumour suppressive microRNA-451a in hypopharyngeal squamous cell carcinoma based on microRNA expression signature. British Journal of Cancer, 2014;111(2):386-394. British Journal of Cancer can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - www.nature.com/; British Journal of Cancer - www.nature.com/bjc/)

Our news journalists report that additional information may be obtained by contacting I. Fukumoto, Kagoshima University, Grad Sch Med & Dental Sci, Dept. of Urol, Kagoshima 890, Japan. Additional authors for this research include T. Kinoshita, T. Hanazawa, N. Kikkawa, T. Chiyomaru, H. Enokida, N. Yamamoto, Y. Goto, R. Nishikawa, M. Nakagawa, Y. Okamoto and N. Seki (see also Biotechnology).

Keywords for this news article include: Asia, Biotechnology, Japan, Genetics, Oncology, Kagoshima, Cancer Gene Therapy, Squamous Cell Carcinoma

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Gene Therapy Week


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