News Column

Study Findings from NHS Foundation Trust Provide New Insights into Blood Transfusion (Transfusion and coagulation management in liver transplantation)

August 20, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Transfusion Medicine are presented in a new report. According to news originating from London, United Kingdom, by NewsRx correspondents, research stated, "There is wide variation in the management of coagulation and blood transfusion practice in liver transplantation. The use of blood products intraoperatively is declining and transfusion free transplantations take place ever more frequently."

Our news journalists obtained a quote from the research from NHS Foundation Trust, "Allogenic blood products have been shown to increase morbidity and mortality. Primary haemostasis, coagulation and fibrinolysis are altered by liver disease. This, combined with intraoperative disturbances of coagulation, increases the risk of bleeding. Meanwhile, the rebalancing of coagulation homeostasis can put patients at risk of hypercoagulability and thrombosis. The application of the principles of patient blood management to transplantation can reduce the risk of transfusion. This includes: preoperative recognition and treatment of anaemia, reduction of perioperative blood loss and the use of restrictive haemoglobin based transfusion triggers. The use of point of care coagulation monitoring using whole blood viscoelastic testing provides a picture of the complete coagulation process by which to guide and direct coagulation management. Pharmacological methods to reduce blood loss include the use of anti-fibrinolytic drugs to reduce fibrinolysis, and rarely, the use of recombinant factor VIIa. Factor concentrates are increasingly used; fibrinogen concentrates to improve clot strength and stability, and prothrombin complex concentrates to improve thrombin generation. Non-pharmacological methods to reduce blood loss include surgical utilisation of the piggyback technique and maintenance of a low central venous pressure. The use of intraoperative cell salvage and normovolaemic haemodilution reduces allogenic blood transfusion."

According to the news editors, the research concluded: "Further research into methods of decreasing blood loss and alternatives to blood transfusion remains necessary to continue to improve outcomes after transplantation."

For more information on this research see: Transfusion and coagulation management in liver transplantation. World Journal of Gastroenterology, 2014;20(20):6146-58. (Baishideng Publishing Group -; World Journal of Gastroenterology -

The news correspondents report that additional information may be obtained from B. Clevenger, Ben Clevenger, Susan V Mallett, Dept. of Anaesthesia, Royal Free NHS Foundation Trust, London NW3 2QG, UK (see also Transfusion Medicine).

Keywords for this news article include: London, Europe, Surgery, Pharmacology, United Kingdom, Medical Devices, Organ Transplant, Blood Transfusion, Biological Therapy, Transfusion Medicine, Liver Transplantation, Tissue Transplantation, Digestive System Surgical Procedures.

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Source: Biotech Week

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