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Study Data from Nanyang Technological University Provide New Insights into Proteomics (Identifying and engineering promoters for high level and...

August 21, 2014



Study Data from Nanyang Technological University Provide New Insights into Proteomics (Identifying and engineering promoters for high level and sustainable therapeutic recombinant protein production in cultured mammalian cells)

By a News Reporter-Staff News Editor at Gene Therapy Weekly -- New research on Proteomics is the subject of a report. According to news reporting out of Singapore, Singapore, by NewsRx editors, research stated, "Promoters are essential on plasmid vectors to initiate transcription of the transgenes when generating therapeutic recombinant proteins expressing mammalian cell lines. High and sustained levels of gene expression are desired during therapeutic protein production while gene expression is useful for cell engineering."

Our news journalists obtained a quote from the research from Nanyang Technological University, "As many finely controlled promoters exhibit cell and product specificity, new promoters need to be identified, optimized and carefully evaluated before use. Suitable promoters can be identified using techniques ranging from simple molecular biology methods to modern high-throughput omics screenings. Promoter engineering is often required after identification to either obtain high and sustained expression or to provide a wider range of gene expression."

According to the news editors, the research concluded: "This review discusses some of the available methods to identify and engineer promoters for therapeutic recombinant protein expression in mammalian cells."

For more information on this research see: Identifying and engineering promoters for high level and sustainable therapeutic recombinant protein production in cultured mammalian cells. Biotechnology Letters, 2014;36(8):1569-1579. Biotechnology Letters can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Biotechnology Letters - www.springerlink.com/content/0141-5492/)

Our news journalists report that additional information may be obtained by contacting S.C.L. Ho, Nanyang Technological University, Sch Chem & Biomed Engn, Singapore 637459, Singapore (see also Proteomics).

Keywords for this news article include: Asia, Proteomics, Engineering, Recombinant Proteins

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Gene Therapy Weekly


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