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Study Data from Dibrugarh University Provide New Insights into Drug Delivery Systems (Crosslinked thiolated starch coated Fe3O4 magnetic...

August 20, 2014



Study Data from Dibrugarh University Provide New Insights into Drug Delivery Systems (Crosslinked thiolated starch coated Fe3O4 magnetic nanoparticles: Effect of montmorillonite and crosslinking density on drug delivery properties)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Drugs and Therapies. According to news reporting from Dibrugarh, India, by NewsRx journalists, research stated, "The anti-tuberculosis drug isoniazid was incorporated within crosslinked thiolated starch coated magnetic iron oxide nanoparticles, aiming to reach a controlled drug delivery system. The coated magnetic nanoparticles were characterized by FTIR, XRD study, and Vibrating Sample Magnetometer (VSM)."

The news correspondents obtained a quote from the research from Dibrugarh University, "The morphology and dimensional characteristics of the nanoparticles were analyzed by SEM, TEM, and Dynamic Light Scattering (DLS) method. The drug release mechanism was studied at pH 1.2 and pH 7.4 for different time periods by UV-visible spectrophotometer. Cytotoxicity study was performed by MTT assay analysis. Mucoadhesivity study was done by in vitro wash-off and ex vivo mucoadhesive test. The incorporation of montmorillonite and crosslinking of the nanoparticles were found to improve the cell viability, mucoadhesivity, and drug release properties."

According to the news reporters, the research concluded: "The properties of the prepared nanoparticles suggested their prospects for biomedical applications."

For more information on this research see: Crosslinked thiolated starch coated Fe3O4 magnetic nanoparticles: Effect of montmorillonite and crosslinking density on drug delivery properties. Starch-Starke, 2014;66(7-8):760-771. Starch-Starke can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany (see also Drugs and Therapies).

Our news journalists report that additional information may be obtained by contacting C. Saikia, Dibrugarh Univ, Dept. of Pharmaceut Sci, Dibrugarh, Assam, India. Additional authors for this research include A. Hussain, A. Ramteke, H.K. Sharma and T.K. Maji.

Keywords for this news article include: Asia, India, Dibrugarh, Nanoparticle, Nanotechnology, Drugs and Therapies, Drug Delivery Systems, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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