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Studies in the Area of Small Interference RNAs (siRNAs) Reported from China University of Science and Technology (Matrix metalloproteinase...

August 20, 2014



Studies in the Area of Small Interference RNAs (siRNAs) Reported from China University of Science and Technology (Matrix metalloproteinase 2-responsive micelle for siRNA delivery)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Small Interference RNAs (siRNAs). According to news reporting out of Anhui, People's Republic of China, by NewsRx editors, research stated, "Systemic delivery of small interfering RNA (siRNA) into cancer cells remains the major obstacle to siRNA drug development. An ideal siRNA delivery vehicle for systemic administration should have long circulation time in blood, accumulate at tumor site, and sufficiently internalize into cancer cells for highefficiency of gene silence."

Our news journalists obtained a quote from the research from the China University of Science and Technology, "Herein, we report a core shell Micelleplex delivery system that made from block copolymer bearing poly(ethylene glycol) (PEG), matrix metalloproteinase 2 (MMP-2)-degradable peptide PLG*LAG, cationic cell penetrating peptide polyarginine r9 and poly(e-caprolactone) (PCL) for siRNA delivery. We show clear evidences in vitro and in vivo to prove that the micelle carrying siRNA can circulate enough time in blood, enrich accumulation at tumor sites, shed the PEG layer when triggered by tumor overexpressing MMP-2, and then the exposing cell penetrating peptide r9 enhanced cellular uptake of siRNA."

According to the news editors, the research concluded: "Accordingly, this design strategy enhances the inhibition of breast tumor growth following systemic injection of this system carrying siRNA against Polo-like kinase 1, which demonstrating this Micelleplex can be a potential delivery system for systemic siRNA delivery in cancer therapy."

For more information on this research see: Matrix metalloproteinase 2-responsive micelle for siRNA delivery. Biomaterials, 2014;35(26):7622-7634. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)

Our news journalists report that additional information may be obtained by contacting H.X. Wang, China University of Science & Technology, High Field Magnet Lab, CAS, Hefei 230026, Anhui, People's Republic of China. Additional authors for this research include X.Z. Yang, C.Y. Sun, C.Q. Mao, Y.H. Zhu and J. Wang (see also Small Interference RNAs (siRNAs)).

Keywords for this news article include: Asia, Anhui, Cancer, Genetics, Oncology, Proteomics, Gelatinases, Collagenases, Metalloproteases, Peptide Hydrolases, Enzymes and Coenzymes, Metalloendopeptidases, People's Republic of China, Matrix Metalloproteinase 2, Small Interference RNAs (siRNAs), Secreted Matrix Metalloproteinases

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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