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Studies from Zhejiang University College of Medicine in the Area of Colon Cancer Described (Protein fingerprint of colorectal cancer, adenomatous...

August 19, 2014



Studies from Zhejiang University College of Medicine in the Area of Colon Cancer Described (Protein fingerprint of colorectal cancer, adenomatous polyps, and normal mucosa using ProteinChip analysis on laser capture microdissected cells)

By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Oncology have been published. According to news reporting out of Hangzhou, People's Republic of China, by NewsRx editors, research stated, "To find new biomarkers and establish histopathology protein fingerprint models for early detection of colorectal cancer (CRC), laser capture microdissection (LCM) was utilized to obtain 3 groups of cells of interest--CRC tissues, their adjacent normal colorectal tissues, and their adjacent adenomatous polyps tissues--from the same 12 CRC patients. Each sample was then detected by surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF-MS) technology and CM10 protein chip as well as bioinformatics tools."

Our news journalists obtained a quote from the research from the Zhejiang University College of Medicine, "Model 1 formed by 15 protein peaks could be used to distinguish CRC tissues from normal tissues. The diagnostic pattern constructed using support vector machine (SVM) including the 15 proteins showed maximum Youden index (YI). Model 2 formed by 14 protein peaks could be used to distinguish CRC tissues from adenomatous polyps tissues. The two patterns were validated and the results showed that the sensitivity and specificity were both 100.0%. Model 3 formed by 15 protein peaks could distinguish adenomatous polyps tissues from normal tissues with a sensitivity of 92.3% and specificity of 100.0%. The protein peaks m/z 3570 and 5224 were identified in screening for changes during cancer progression. Peak 5224 was significantly upregulated in CRC. However, peak 3570 was significantly downregulated in CRC."

According to the news editors, the research concluded: "LCM technology coupled with SELDI protein chip and bioinformatics approaches could effectively screen the differentially expressed protein profiles and establish molecular diagnosis models with high sensitivity and specificity for CRC."

For more information on this research see: Protein fingerprint of colorectal cancer, adenomatous polyps, and normal mucosa using ProteinChip analysis on laser capture microdissected cells. Discovery Medicine, 2014;17(95):223-31 (see also Oncology).

Our news journalists report that additional information may be obtained by contacting W. Xu, Dept. of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, Zhejiang 310009, People's Republic of China. Additional authors for this research include Y. Chen, W. He, Z. Fu, T. Pan, H. He, J. Yu, Q. Wei, S. Zheng and S. Zhang.

Keywords for this news article include: Asia, Hangzhou, Oncology, Colorectal, Colon Cancer, Protein Chips, Nanotechnology, Gastroenterology, Emerging Technologies, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Weekly


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