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Studies from University of Waterloo Provide New Data on DNA Research (Platinated DNA oligonucleotides: new probes forming ultrastable conjugates with...

August 19, 2014



Studies from University of Waterloo Provide New Data on DNA Research (Platinated DNA oligonucleotides: new probes forming ultrastable conjugates with graphene oxide)

By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in DNA Research. According to news originating from Waterloo, Canada, by NewsRx correspondents, research stated, "Metal containing polymers have expanded the property of polymers by involving covalently associated metal complexes. DNA is a special block copolymer."

Our news journalists obtained a quote from the research from the University of Waterloo, "While metal ions are known to influence DNA, little is explored on its polymer property when strong metal complexes are associated. In this work, we study cisplatin modified DNA as a new polymer and probe. Out of the complexes formed between cisplatin-A15, HAuCl4-A15, Hg(2+)-T15 and Ag(+)-C15, only the cisplatin adduct is stable under the denaturing gel electrophoresis condition. Each Pt-nucleobase bond gives a positive charge and thus makes DNA a zwitterionic polymer. This allows ultrafast adsorption of DNA by graphene oxide (GO) and the adsorbed complex is highly stable. Non-specific DNA, protein, surfactants and thiolated compounds cannot displace platinated DNA from GO, while non-modified DNA is easily displaced in most cases. The stable GO/DNA conjugate is further tested for surface hybridization."

According to the news editors, the research concluded: "This is the first demonstration of using metallated DNA as a polymeric material for interfacing with nanoscale materials."

For more information on this research see: Platinated DNA oligonucleotides: new probes forming ultrastable conjugates with graphene oxide. Nanoscale, 2014;6(12):7079-84. (Royal Society of Chemistry - www.rsc.org/; Nanoscale - pubs.rsc.org/en/journals/journalissues/nr)

The news correspondents report that additional information may be obtained from F. Wang, Dept. of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada (see also DNA Research).

Keywords for this news article include: Canada, Ontario, Waterloo, DNA Research, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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