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Studies from University of Colorado Have Provided New Information about Cancer Gene Therapy (Targeting of erbB3 receptor to overcome resistance in...

August 18, 2014

Studies from University of Colorado Have Provided New Information about Cancer Gene Therapy (Targeting of erbB3 receptor to overcome resistance in cancer treatment)

By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Investigators discuss new findings in Biotechnology. According to news reporting from Aurora, Colorado, by NewsRx journalists, research stated, "The erbB receptors, including the epidermal growth factor receptor (EGFR), erbB2 (also known as HER2/neu), erbB3 (or HER3), and erbB4 (or HER4), are often aberrantly activated in a wide variety of human cancers. They are excellent targets for selective anti-cancer therapies because of their transmembrane location and pro-oncogenic activity."

The news correspondents obtained a quote from the research from the University of Colorado, "While several therapeutic agents against erbB2 and/or EGFR have been used in the treatment of human cancers with efficacy, there has been relatively less emphasis on erbB3 as a molecular target. Elevated expression of erbB3 is frequently observed in various malignancies, where it promotes tumor progression via interactions with other receptor tyrosine kinases (RTKs) due to its lack of or weak intrinsic kinase activity. Studies on the underlying mechanisms implicate erbB3 as a major cause of treatment failure in cancer therapy, mainly through activation of the PI-3 K/Akt, MEK/MAPK, and Jak/Stat signaling pathways as well as Src kinase. It is believed that inhibition of erbB3 signaling may be required to overcome therapeutic resistance and effectively treat cancers. To date, no erbB3-targeted therapy has been approved for cancer treatment. Targeting of erbB3 receptor with a monoclonal antibody (Ab) is the only strategy currently under preclinical study and clinical evaluation."

According to the news reporters, the research concluded: "In this review, we focus on the role of erbB3-initiated signaling in the development of cancer drug resistance and discuss the latest advances in identifying therapeutic strategies inactivating erbB3 to overcome the resistance and enhance efficacy of cancer therapeutics."

For more information on this research see: Targeting of erbB3 receptor to overcome resistance in cancer treatment. Molecular Cancer, 2014;13():105. (BioMed Central -; Molecular Cancer -

Our news journalists report that additional information may be obtained by contacting J. Ma, Dept. of Pathology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States. Additional authors for this research include H. Lyu, J. Huang and B. Liu (see also Biotechnology).

Keywords for this news article include: Biotechnology, Aurora, Kinase, Colorado, Oncology, Therapeutics, United States, Cancer Gene Therapy, Enzymes and Coenzymes, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Cancer Gene Therapy Week

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