Studies from Sharif University of Technology Have Provided New Information about Cephalosporins (Tantalum Electrodes Modified With Well-Aligned Carbon Nanotube-Au Nanoparticles: Application to the Highly Sensitive Electrochemical Determination ...)
By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Antibiotics. According to news reporting from Tehran, Iran, by NewsRx journalists, research stated, "Carbon nanotube/nanoparticle hybrid materials have been proven to exhibit high electrocatalytic activity suggesting broad potential applications in the field of electroanalysis. For the first time, modification of Ta electrode with aligned multi-walled carbon nanotubes/Au nanoparticles introduced for the sensitive determination of the antibiotic drug, cefazolin (CFZ)."
The news correspondents obtained a quote from the research from the Sharif University of Technology, "The electrochemical response characteristics of the modified electrode toward CFZ were investigated by means of cyclic and linear sweep voltammetry. The modified electrode showed an efficient catalytic activity for the reduction of CFZ, leading to a remarkable decrease in reduction overpotential and a significant increase of peak current. Under optimum conditions, the highly sensitive modified electrode showed a wide linear range from 50 pM to 50 mu M with a sufficiently low detection limit of 1 +/- 0.01 pM (S/N = 3). The results indicated that the prepared electrode presents suitable characteristics in terms of sensitivity (458.2 +/- 2.6 mu Acm(-2)/mu M), accuracy, repeatability (RSD of 1.8 %), reproducibility (RSD of 2.9 %), stability (14 days), and good catalytic activity in physiological conditions."
According to the news reporters, the research concluded: "The method was successfully applied for accurate determination of trace amounts of CFZ in pharmaceutical and clinical preparations without the necessity for samples pretreatment or any time-consuming extraction or evaporation steps prior to the analysis."
For more information on this research see: Tantalum Electrodes Modified With Well-Aligned Carbon Nanotube-Au Nanoparticles: Application to the Highly Sensitive Electrochemical Determination of Cefazolin. Applied Biochemistry and Biotechnology, 2014;173(6):1511-1528. Applied Biochemistry and Biotechnology can be contacted at: Humana Press Inc, 999 Riverview Drive Suite 208, Totowa, NJ 07512, USA. (Springer - www.springer.com; Applied Biochemistry and Biotechnology - www.springerlink.com/content/0273-2289/)
Our news journalists report that additional information may be obtained by contacting H. Fayazfar, Sharif Univ Technol, Mat Sci & Engn Department, Tehran, Iran. Additional authors for this research include A. Afshar and A. Dolati (see also Antibiotics).
Keywords for this news article include: Iran, Asia, Antiinfectives, Drugs, Tehran, Amides, Therapy, Cefazolin, Chemistry, Fullerenes, Nanoparticle, Nanotechnology, Electrochemical, Carbon Nanotubes, Organic Chemicals, Emerging Technologies, Beta-Lactam Antibiotics, First Generation Cephalosporins
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