Studies from National Taiwan University of Science and Technology Further Understanding of Drug Delivery Systems (Doxorubicin-Loaded Nanogel Assemblies with pH/Thermo-triggered Payload Release for Intracellular Drug Delivery)
By a News Reporter-Staff News Editor at Biotech Week -- New research on Drugs and Therapies is the subject of a report. According to news reporting originating in Taipei, Taiwan, by NewsRx journalists, research stated, "For improving intracellular doxorubicin (DOX) delivery, DOX-encapsulated nanogel assemblies with pH/thermo-responsive drug release are developed. DOX and a graft copolymer comprising acrylic acid (AAc) and 2-methacryloyloxyethyl acrylate (MEA) units as the backbone and with poly(N -isopropylacrylamide) (PNIPAAm) and monomethoxy poly(ethylene glycol) as the grafts at pH 7.4 and 4 degrees C undergo electrostatically induced co-association into copolymer/DOX nanocomplexes."
The news reporters obtained a quote from the research from the National Taiwan University of Science and Technology, "After being crosslinked by polymerization of the MEA moieties, the complex nanoconstructs exhibit a unique nanogel-like architecture. Taking advantage of the extensive electrostatic attraction of the DOX molecules with ionized AAc residues and pi-pi stacking among copolymer-bound DOX molecules, the DOX-loaded nanogels show a relatively high payload content. With the milieu pH being reduced from 7.4 to 4.7, the drug release is appreciably promoted due to the massive disruption of ionic AAc/DOX pairings. The thermo-evolved phase transition of the PNIPAAm grafts further accelerates drug elution, particularly at pH 4.7. In vitro characterization indicates that the DOX-embedded nanogels endocytosed by HeLa cells can progressively release DOX within acidic organelles. As a result, the viability of cancer cells treated with DOX-loaded nanoparticles can be further reduced by prolonging incubation time."
According to the news reporters, the research concluded: "This work demonstrates the great potential of the DOX-loaded nanogel assemblies for effective intracellular drug delivery."
For more information on this research see: Doxorubicin-Loaded Nanogel Assemblies with pH/Thermo-triggered Payload Release for Intracellular Drug Delivery. Macromolecular Chemistry and Physics, 2014;215(13):1332-1341. Macromolecular Chemistry and Physics can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Macromolecular Chemistry and Physics - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-3935)
Our news correspondents report that additional information may be obtained by contacting W.H. Chiang, Natl Taiwan Univ Sci & Technol, Dept. of Chem Engn, Taipei 106, Taiwan. Additional authors for this research include W.C. Huang, Y.J. Chang, M.Y. Shen, H.H. Chen, C.S. Chern and H.C. Chiu (see also Drugs and Therapies).
Keywords for this news article include: Asia, Antibiotics - Antineoplastics, Pharmaceuticals, Taipei, Taiwan, Drugs and Therapies, Drug Delivery Systems, Doxorubicin Hydrochloride
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