Studies from National Center for Scientific Research (CNRS) Yield New Information about Cancer Gene Therapy (Cytotoxic Triosmium Carbonyl Clusters: A Structure-Activity Relationship Study)
By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Investigators publish new report on Biotechnology. According to news reporting originating in Paris, France, by NewsRx journalists, research stated, "A structure-activity relationship (SAR) study of the triosmium carbonyl cluster Os-3(CO)(10)(NCCH3)(2) was carried out with a series of clusters of the general formula Os-3(CO)(12-n)L-n, cationic osmium clusters and a hemi-labile maltolato-Os cluster. The SAR results showed that good solubility in DMSO and at least one vacant site are required for cytotoxicity."
The news reporters obtained a quote from the research from National Center for Scientific Research (CNRS), "In vitro evaluation of these new compounds showed that some are selectively active against estrogen receptor (ER)-independent MDA-MB231 breast cancer cell lines relative to ER-dependent MCF-7 breast cancer cells, suggesting that the compounds have a different biological target specific to MDA-MB-231 cells. In particular, the maltolato cluster exhibits strong antiproliferative activity, with an IC50 value of 3 mm after only 24 h incubation. Additionally, biochemical assays conducted with the cationic cluster show that it induces apoptosis, although a biological target has not yet been identified."
According to the news reporters, the research concluded: "Further research to establish the molecular targets of these compounds and to develop improved organometallic clusters as potential breast cancer therapeutics is underway."
For more information on this research see: Cytotoxic Triosmium Carbonyl Clusters: A Structure-Activity Relationship Study. Chemmedchem, 2014;9(7):1453-1457. Chemmedchem can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Chemmedchem - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1860-7187)
Our news correspondents report that additional information may be obtained by contacting H.Z.S. Lee, Ecole Natl Super Chim Paris, Lab Charles Friedel, UMR CNRS 7223, F-75231 Paris 05, France. Additional authors for this research include W.K. Leong, S. Top and A. Vessieres (see also Biotechnology).
Keywords for this news article include: Biotechnology, Paris, France, Europe, Oncology, Breast Cancer, Women's Health, Cancer Gene Therapy
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