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Studies from K.R. Beavers and Co-Authors Have Provided New Information about Drug Delivery Systems (In Situ Synthesis of Peptide Nucleic Acids in...

August 21, 2014



Studies from K.R. Beavers and Co-Authors Have Provided New Information about Drug Delivery Systems (In Situ Synthesis of Peptide Nucleic Acids in Porous Silicon for Drug Delivery and Biosensing)

By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Investigators publish new report on Drugs and Therapies. According to news originating from La Vergne, Tennessee, by NewsRx correspondents, research stated, "Peptide nucleic acids (PNA) are a unique class of synthetic molecules that have a peptide backbone and can hybridize with nucleic adds. Here, a versatile method has been developed for the automated, in situ synthesis of PNA from a porous silicon (PSi) substrate for applications in gene therapy and biosensing."

Our news journalists obtained a quote from the research, "Non-destructive optical measurements were performed to monitor single base additions of PNA initiated from (3-aminopropyl)triethoxysilane attached to the surface of PSi films, and mass spectrometry was conducted to verify synthesis of the desired sequence. Comparison of in situ synthesis to postsynthesis surface conjugation of the full PNA molecules showed that surface mediated, in situ PNA synthesis increased loading 8-fold. For therapeutic proof-of-concept, controlled PNA release from PSi films was characterized in phosphate buffered saline, and PSi nanoparticles fabricated from PSi films containing in situ grown PNA complementary to micro-RNA (miR) 122 generated significant anti-miR activity in a Huh7 psiCHECK-miR122 cell line. The applicability of this platform for biosensing was also demonstrated using optical measurements that indicated selective hybridization of complementary DNA target molecules to PNA synthesized in situ on PSi films."

According to the news editors, the research concluded: "These collective data confirm that we have established a novel PNA-PSi platform with broad utility in drug delivery and biosensing."

For more information on this research see: In Situ Synthesis of Peptide Nucleic Acids in Porous Silicon for Drug Delivery and Biosensing. Bioconjugate Chemistry, 2014;25(7):1192-1197. Bioconjugate Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Bioconjugate Chemistry - www.pubs.acs.org/journal/bcches)

The news correspondents report that additional information may be obtained from K.R. Beavers, LaVergne High Sch, La Vergne, TN 37086, United States. Additional authors for this research include J.W. Mares, C.M. Swartz, Y.L. Zhao, S.M. Weiss and C.L. Duvall (see also Drugs and Therapies).

Keywords for this news article include: Peptides, Proteins, La Vergne, Tennessee, Proteomics, United States, Nanotechnology, Porous Silicon, Drugs and Therapies, Drug Delivery Systems, Emerging Technologies, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Gene Therapy Weekly


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