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Studies from J.N. Wittbrodt et al Add New Findings in the Area of Biotechnology (Generation of orientation tools for automated zebrafish screening...

August 20, 2014



Studies from J.N. Wittbrodt et al Add New Findings in the Area of Biotechnology (Generation of orientation tools for automated zebrafish screening assays using desktop 3D printing)

By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Technology are discussed in a new report. According to news reporting from Karlsruhe, Germany, by NewsRx journalists, research stated, "The zebrafish has been established as the main vertebrate model system for whole organism screening applications. However, the lack of consistent positioning of zebrafish embryos within wells of microtiter plates remains an obstacle for the comparative analysis of images acquired in automated screening assays."

The news correspondents obtained a quote from the research, "While technical solutions to the orientation problem exist, dissemination is often hindered by the lack of simple and inexpensive ways of distributing and duplicating tools. Here, we provide a cost effective method for the production of 96-well plate compatible zebrafish orientation tools using a desktop 3D printer. The printed tools enable the positioning and orientation of zebrafish embryos within cavities formed in agarose. Their applicability is demonstrated by acquiring lateral and dorsal views of zebrafish embryos arrayed within microtiter plates using an automated screening microscope. This enables the consistent visualization of morphological phenotypes and reporter gene expression patterns. The designs are refined versions of previously demonstrated devices with added functionality and strongly reduced production costs. All corresponding 3D models are freely available and digital design can be easily shared electronically. In combination with the increasingly widespread usage of 3D printers, this provides access to the developed tools to a wide range of zebrafish users."

According to the news reporters, the research concluded: "Finally, the design files can serve as templates for other additive and subtractive fabrication methods."

For more information on this research see: Generation of orientation tools for automated zebrafish screening assays using desktop 3D printing. Bmc Biotechnology, 2014;14():36. (BioMed Central - www.biomedcentral.com/; Bmc Biotechnology - www.biomedcentral.com/bmcbiotechnol/)

Our news journalists report that additional information may be obtained by contacting J.N. Wittbrodt, Acquifer AG, Karlsruhe, Germany. Additional authors for this research include U. Liebel and J. Gehrig (see also Technology).

Keywords for this news article include: Europe, Germany, Karlsruhe, Technology.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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