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Studies from Chinese Academy of Sciences in the Area of Drug Delivery Systems Described (Mesoporous NaYbF4@NaGdF4 core-shell up-conversion...

August 20, 2014



Studies from Chinese Academy of Sciences in the Area of Drug Delivery Systems Described (Mesoporous NaYbF4@NaGdF4 core-shell up-conversion nanoparticles for targeted drug delivery and multimodal imaging)

By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Drugs and Therapies are discussed in a new report. According to news reporting out of Beijing, People's Republic of China, by NewsRx editors, research stated, "We developed a facile strategy to obtain a new kind of mesoporous core-shell structured up-conversion nanoparticles (mUCNPs), composed of a NaYbF4:2%Er core and a mesoporous NaGdF4 shell. This mesoporous shell not only enhanced the up-conversion luminescence but also endowed many other functionalities of the nanoparticles such as drug delivery and bio-imaging capabilities."

Our news journalists obtained a quote from the research from the Chinese Academy of Sciences, "Moreover, after being conjugated with polyethylenimine (PEI) and folic acid (FA), core-shell mUCNPs exhibited good water dispersibility, enhanced drug delivery efficiency, and remarkable targeting ability to cancer cells. To certify the folate receptors (FR)-mediated targeted drug delivery, cell viability assay, cell up-conversion luminescence imaging and flow cytometry analysis were carried out."

According to the news editors, the research concluded: "Furthermore, apart from the application for targeted drug delivery, the as-prepared core-shell mUCNPs could also be employed as the contrast agents for X-ray computed tomography (CT) and magnetic resonance (MR) imaging, because of the strong X-ray attenuation ability of Yb and high longitudinal molar relaxivity (r(1)) of Gd in the nanoparticles, providing the potential for simultaneously bio-imaging and cancer-targeting therapy."

For more information on this research see: Mesoporous NaYbF4@NaGdF4 core-shell up-conversion nanoparticles for targeted drug delivery and multimodal imaging. Biomaterials, 2014;35(26):7666-7678. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)

Our news journalists report that additional information may be obtained by contacting L.J. Zhou, Univ Chinese Academy Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, People's Republic of China. Additional authors for this research include X.P. Zheng, Z.J. Gu, W.Y. Yin, X. Zhang, L.F. Ruan, Y.B. Yang, Z.B. Hu and Y.L. Zhao (see also Drugs and Therapies).

Keywords for this news article include: Asia, Beijing, Nanoparticle, Nanotechnology, Drugs and Therapies, Drug Delivery Systems, Emerging Technologies, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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