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Researchers' Work from Harvard Stem Cell Institute Focuses on Biomedicine and Biomedical Engineering (Microcavity substrates casted from...

August 20, 2014



Researchers' Work from Harvard Stem Cell Institute Focuses on Biomedicine and Biomedical Engineering (Microcavity substrates casted from self-assembled microsphere monolayers for spheroid cell culture)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Biotechnology. According to news reporting from Cambridge, Massachusetts, by NewsRx journalists, research stated, "Multicellular spheroids are an important 3-dimensional cell culture model that reflects many key aspects of in vivo microenvironments. This paper presents a scalable, self-assembly based approach for fabricating microcavity substrates for multicellular spheroid cell culture."

The news correspondents obtained a quote from the research from Harvard Stem Cell Institute, "Hydrophobic glass microbeads were self-assembled into a tightly packed monolayer through the combined actions of surface tension, gravity, and lateral capillary forces at the water-air interface of a polymer solution. The packed bead monolayer was subsequently embedded in the dried polymer layer. The surface was used as a template for replicating microcavity substrates with perfect spherical shapes. We demonstrated the use of the substrate in monitoring the formation process of tumor spheroids, a proof-of-concept scale-up fabrication procedure into standard microplate formats, and its application in testing cancer drug responses in the context of bone marrow stromal cells."

According to the news reporters, the research concluded: "The presented technique offers a simple and effective way of forming high-density uniformly-sized spheroids without microfabrication equipment for biological and drug screening applications."

For more information on this research see: Microcavity substrates casted from self-assembled microsphere monolayers for spheroid cell culture. Biomedical Microdevices, 2014;16(4):609-615. Biomedical Microdevices can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Biomedical Microdevices - www.springerlink.com/content/1387-2176/)

Our news journalists report that additional information may be obtained by contacting K. Shen, Harvard Stem Cell Inst, Cambridge, MA 02138, United States. Additional authors for this research include J. Lee, M.L. Yarmush and B. Parekkadan (see also Biotechnology).

Keywords for this news article include: Biotechnology, Cambridge, Massachusetts, United States, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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