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Researchers from University of Valencia Detail New Studies and Findings in the Area of Cancer Gene Therapy (Comparative antitumor effect among...

August 18, 2014



Researchers from University of Valencia Detail New Studies and Findings in the Area of Cancer Gene Therapy (Comparative antitumor effect among GM-CSF, IL-12 and GM-CSF+IL-12 genetically modified tumor cell vaccines)

By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Researchers detail new data in Biotechnology. According to news reporting originating from Valencia, Spain, by NewsRx correspondents, research stated, "Genetically modified cells have been shown to be one of the most effective cancer vaccine strategies. An evaluation is made of the efficacy of both preventive and therapeutic antitumor vaccines against murine melanoma, using C57BL/6 mice and irradiated B16 tumor cells expressing granulocyte and macrophage colony-stimulating factor (GM-CSF), interleukin-12 (IL-12) or both."

Our news editors obtained a quote from the research from the University of Valencia, "Tumor was transplanted by the injection of wild-type B16 cells. Tumor growth and survival were measured to evaluate the efficacy of vaccination. Specific humoral response and immunoglobulin G (IgG) switch were evaluated measuring total IgG and IgG1 and IgG2a subtypes against tumor membrane proteins of B16 cells. In preventive vaccination, all treated groups showed delayed tumor growth. In addition, the group vaccinated to express only GM-CSF achieved 100% animal survival (p

According to the news editors, the research concluded: "No differences in classical regulatory T cells were found among the different groups."

For more information on this research see: Comparative antitumor effect among GM-CSF, IL-12 and GM-CSF+IL-12 genetically modified tumor cell vaccines. Cancer Gene Therapy, 2013;20(10):576-81. (Nature Publishing Group - www.nature.com/; Cancer Gene Therapy - www.nature.com/cgt/)

The news editors report that additional information may be obtained by contacting A. Miguel, Departamento de Farmacologia, Facultad de Medicina, Universidad de Valencia, Valencia, Spain. Additional authors for this research include M.J. Herrero, L. Sendra, R. Botella, R. Algas, M. Sanchez and S.F Alino (see also Biotechnology).

Keywords for this news article include: Biotechnology, Spain, Europe, Valencia.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Gene Therapy Week


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