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Researchers from University of Padua Report on Findings in Adrenal Cortex Hormones (A living biosensor model to dynamically trace glucocorticoid...

August 20, 2014



Researchers from University of Padua Report on Findings in Adrenal Cortex Hormones (A living biosensor model to dynamically trace glucocorticoid transcriptional activity during development and adult life in zebrafish)

By a News Reporter-Staff News Editor at Biotech Week -- A new study on Adrenal Cortex Hormones is now available. According to news reporting originating in Padua, Italy, by NewsRx journalists, research stated, "Glucocorticoids (GCs) modulate many cellular processes through the binding of the glucocorticoid receptor (GR) to specific responsive elements located upstream of the transcription starting site or within an intron of GC target genes. Here we describe a transgenic fish line harboring a construct with nine GC-responsive elements (GREs) upstream of a reporter (EGFP) coding sequence."

The news reporters obtained a quote from the research from the University of Padua, "Transgenic fish exhibit strong fluorescence in many known GC-responsive organs. Moreover, its enhanced sensitivity allowed the discovery of novel GC-responsive tissue compartments, such as fin, eyes, and otic vesicles. Long-term persistence of transgene expression is seen during adult stages in several organs. Pharmacological and genetic analysis demonstrates that the transgenic line is highly responsive to drug administration and molecular manipulation."

According to the news reporters, the research concluded: "Moreover, reporter expression is sensitively and dynamically modulated by the photoperiod, thus proving that these fish are an in vivo valuable platform to explore GC responsiveness to both endogenous and exogenous stimuli."

For more information on this research see: A living biosensor model to dynamically trace glucocorticoid transcriptional activity during development and adult life in zebrafish. Molecular and Cellular Endocrinology, 2014;392(1-2):60-72. Molecular and Cellular Endocrinology can be contacted at: Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland. (Elsevier - www.elsevier.com; Molecular and Cellular Endocrinology - www.elsevier.com/wps/product/cws_home/506028)

Our news correspondents report that additional information may be obtained by contacting F. Benato, University of Padua, Dept. of Mol Med, I-35131 Padua, Italy. Additional authors for this research include E. Colletti, T. Skobo, E. Moro, L. Colombo, F. Argenton and L.D. Valle (see also Adrenal Cortex Hormones).

Keywords for this news article include: Padua, Italy, Europe, Biosensing, Bioengineering, Glucocorticoids, Bionanotechnology, Nanobiotechnology, Adrenal Cortex Hormones

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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