Researchers from Rosario National University Describe Findings in Carboxylic Acids (Expanding the chemical diversity of natural esters by engineering a polyketide-derived pathway into Escherichia coli)
By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Carboxylic Acids have been published. According to news originating from Santa Fe, Argentina, by NewsRx correspondents, research stated, "Microbial fatty acid (FA)-derived molecules have emerged as promising alternatives to petroleum-based chemicals for reducing dependence on fossil hydrocarbons. However, native FA biosynthetic pathways often yield limited structural diversity, and therefore restricted physicochemical properties, of the end products by providing only a limited variety of usually linear hydrocarbons."
Our news journalists obtained a quote from the research from Rosario National University, "Here we have engineered into Escherichia cob a mycocerosic polyketide synthase-based biosynthetic pathway from Mycobacterium tuberculosis and redefined its biological role towards the production of multi-methyl-branched-esters (MBEs) with novel chemical structures. Expression of FadD28. Man and PapA5 enzymes enabled the biosynthesis of multi-methyl-branched-FA and their further esterification to an alcohol. The high substrate tolerance of these enzymes towards different FA and alcohol moieties resulted in the biosynthesis of a broad range of MBE."
According to the news editors, the research concluded: "Further metabolic engineering of the MBE producer strain coupled this system to long-chain-alcohol biosynthetic pathways resulting in de nova production of branched wax esters following addition of only propionate."
For more information on this research see: Expanding the chemical diversity of natural esters by engineering a polyketide-derived pathway into Escherichia coli. Metabolic Engineering, 2014;24():97-106. Metabolic Engineering can be contacted at: Academic Press Inc Elsevier Science, 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. (Elsevier - www.elsevier.com; Metabolic Engineering - www.elsevier.com/wps/product/cws_home/622913)
The news correspondents report that additional information may be obtained from S. Menendez-Bravo, Rosario National University, Fac Ciencias Bioquim & Farmaceut, CONICET, IBR Inst Biol Mol & Celular RosarioMicrobiol Div, RA-2000 Rosario, Santa Fe, Argentina. Additional authors for this research include S. Comba, M. Sabatini, A. Arabolaza and H. Gramajo (see also Carboxylic Acids).
Keywords for this news article include: Esters, Santa Fe, Argentina, South America, Carboxylic Acids, Metabolic Engineering
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