News Column

Researchers from Rosario National University Describe Findings in Carboxylic Acids (Expanding the chemical diversity of natural esters by engineering...

August 19, 2014



Researchers from Rosario National University Describe Findings in Carboxylic Acids (Expanding the chemical diversity of natural esters by engineering a polyketide-derived pathway into Escherichia coli)

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Carboxylic Acids have been published. According to news originating from Santa Fe, Argentina, by NewsRx correspondents, research stated, "Microbial fatty acid (FA)-derived molecules have emerged as promising alternatives to petroleum-based chemicals for reducing dependence on fossil hydrocarbons. However, native FA biosynthetic pathways often yield limited structural diversity, and therefore restricted physicochemical properties, of the end products by providing only a limited variety of usually linear hydrocarbons."

Our news journalists obtained a quote from the research from Rosario National University, "Here we have engineered into Escherichia cob a mycocerosic polyketide synthase-based biosynthetic pathway from Mycobacterium tuberculosis and redefined its biological role towards the production of multi-methyl-branched-esters (MBEs) with novel chemical structures. Expression of FadD28. Man and PapA5 enzymes enabled the biosynthesis of multi-methyl-branched-FA and their further esterification to an alcohol. The high substrate tolerance of these enzymes towards different FA and alcohol moieties resulted in the biosynthesis of a broad range of MBE."

According to the news editors, the research concluded: "Further metabolic engineering of the MBE producer strain coupled this system to long-chain-alcohol biosynthetic pathways resulting in de nova production of branched wax esters following addition of only propionate."

For more information on this research see: Expanding the chemical diversity of natural esters by engineering a polyketide-derived pathway into Escherichia coli. Metabolic Engineering, 2014;24():97-106. Metabolic Engineering can be contacted at: Academic Press Inc Elsevier Science, 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. (Elsevier - www.elsevier.com; Metabolic Engineering - www.elsevier.com/wps/product/cws_home/622913)

The news correspondents report that additional information may be obtained from S. Menendez-Bravo, Rosario National University, Fac Ciencias Bioquim & Farmaceut, CONICET, IBR Inst Biol Mol & Celular RosarioMicrobiol Div, RA-2000 Rosario, Santa Fe, Argentina. Additional authors for this research include S. Comba, M. Sabatini, A. Arabolaza and H. Gramajo (see also Carboxylic Acids).

Keywords for this news article include: Esters, Santa Fe, Argentina, South America, Carboxylic Acids, Metabolic Engineering

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


For more stories covering the world of technology, please see HispanicBusiness' Tech Channel



Source: Life Science Weekly


Story Tools






HispanicBusiness.com Facebook Linkedin Twitter RSS Feed Email Alerts & Newsletters