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Researchers from Division of Hematology Report Details of New Studies and Findings in the Area of Stem Cells (Patients with immunoglobulin light...

August 20, 2014



Researchers from Division of Hematology Report Details of New Studies and Findings in the Area of Stem Cells (Patients with immunoglobulin light chain amyloidosis undergoing autologous stem cell transplantation have superior outcomes compared ...)

By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Stem Cell Research have been presented. According to news reporting originating from Rochester, Minnesota, by NewsRx correspondents, research stated, "The underlying plasma cell clones in multiple myeloma (MM) and Ig light-chain amyloidosis (AL) appear to be different not only in terms of 'tumor burden' but also in terms of their underlying biology. High-dose chemotherapy with auto-SCT is one method of reducing the clone size and thereby improving OS."

Our news editors obtained a quote from the research from the Division of Hematology, "Post-auto-SCT outcomes between the two diseases have never been formally compared. Among all patients with a diagnosis of AL or MM who received auto-SCT as primary therapy at the Mayo Clinic, Rochester, there were higher CR rates (40% versus 29%, p

According to the news editors, the research concluded: "This difference in survival is most notable among those patients who achieve CR, suggesting very different plasma cell biology between the two diseases."

For more information on this research see: Patients with immunoglobulin light chain amyloidosis undergoing autologous stem cell transplantation have superior outcomes compared with patients with multiple myeloma: a retrospective review from a tertiary referral center. Bone Marrow Transplantation, 2013;48(10):1302-7. Bone Marrow Transplantation can be contacted at: Nature Publishing Group, 345 Park Avenue South, New York, NY 10010-1707, USA. (Nature Publishing Group - www.nature.com/; Bone Marrow Transplantation - www.nature.com/bmt/)

The news editors report that additional information may be obtained by contacting A. Dispenzieri, Division of Hematology, Dept. of Internal Medicine, Mayo Clinic, Rochester, MN, United States. Additional authors for this research include K. Seenithamby, M.Q. Lacy, S.K. Kumar, F.K. Buadi, S.R. Hayman, D. Dingli, M.R. Litzow, D.A. Gastineau, D.J. Inwards, I.N. Micallef, S.M. Ansell, P.B. Johnston, L.F. Porrata, M.M. Patnaik, W.J. Hogan and M.A Gertz (see also Stem Cell Research).

Publisher contact information for the journal Bone Marrow Transplantation is: Nature Publishing Group, 345 Park Avenue South, New York, NY 10010-1707, USA.

Keywords for this news article include: Surgery, Oncology, Rochester, Minnesota, Immunology, Nephrology, Amyloidosis, United States, Immunoproteins, Serum Globulins, Multiple Myeloma, Paraproteinemias, Vascular Diseases, Stem Cell Research, Cell Transplantation, Hematologic Diseases, Hemostatic Disorders, Hemorrhagic Disorders, Blood Protein Disorders.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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