Researchers from Al-Azhar University Report Details of New Studies and Findings in the Area of Nanoparticles (Development of alginate-reinforced chitosan nanoparticles utilizing W/O nanoemulsification/internal crosslinking technique for ...)
By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Nanoparticles is now available. According to news reporting originating from Cairo, Egypt, by NewsRx correspondents, research stated, "First; to develop rabeprazole (RP)-alginate core coated chitosan nanoparticles (NP) utilizing water in oil (W/O) nanoemulsion technique. Second; formulation of transdermal patches loaded RP-NP that avoid drug peroral acid sensitivity and first pass effect."
Our news editors obtained a quote from the research from Al-Azhar University, "Main methods: The influence of six factors on RP-NP formulation was investigated using Plackett-Burman (PB) design. The studied factors were considered for their effect on particle size (Y1) and loading efficiency (Y2). Formulation optimum desirability was identified; a proposed formulation was prepared and characterized. In vitro permeation of the prepared NP compared with RP was studied. Transdermal patches loaded drug or RP-NP were prepared and characterized. Patches ex vivo permeation through rat skin was studied, and kinetic analysis and permeation mechanism were investigated. Key Finding: Chitosan, oil phase and surfactant to oil ratios had significant effects on Y1, while Y2 was significantly affected by the same variables affecting Y1 and span80-tween80 ratio. Scanning electron microscope imaging illustrated sphericity of the NP. The optimized RP-NP exhibited sustained release pattern. The prepared patches showed a minimal patch to patch variable. Patches loaded RP-NP exhibited substantial skin permeability and controlled drug release, and were in favor of Fickian diffusion."
According to the news editors, the research concluded: "Transdermal patches loaded RP-NP is effective drug delivery and alternative to drug peroral route."
For more information on this research see: Development of alginate-reinforced chitosan nanoparticles utilizing W/O nanoemulsification/internal crosslinking technique for transdermal delivery of rabeprazole. Life Sciences, 2014;110(1):35-43. Life Sciences can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Life Sciences - www.elsevier.com/wps/product/cws_home/525477)
The news editors report that additional information may be obtained by contacting T.A. Ahmed, Al Azhar Univ, Fac Pharm, Dept. of Pharmaceut & Ind Pharm, Cairo, Egypt (see also Nanoparticles).
Keywords for this news article include: Cairo, Egypt, Africa, Nanotechnology, Emerging Technologies
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