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Researchers at Institute for Genetics Target Drug Delivery Systems (Diatomite silica nanoparticles for drug delivery)

August 20, 2014

By a News Reporter-Staff News Editor at Biotech Week -- A new study on Drugs and Therapies is now available. According to news reporting originating from Naples, Italy, by NewsRx correspondents, research stated, "Diatomite is a natural fossil material of sedimentary origin, constituted by fragments of diatom siliceous skeletons. In this preliminary work, the properties of diatomite nanoparticles as potential system for the delivery of drugs in cancer cells were exploited."

Our news editors obtained a quote from the research from Institute for Genetics, "A purification procedure, based on thermal treatments in strong acid solutions, was used to remove inorganic and organic impurities from diatomite and to make them a safe material for medical applications. The micrometric diatomite powder was reduced in nanoparticles by mechanical crushing, sonication, and filtering. Morphological analysis performed by dynamic light scattering and transmission electron microscopy reveals a particles size included between 100 and 300 nm. Diatomite nanoparticles were functionalized by 3-aminopropyltriethoxysilane and labeled by tetramethylrhodamine isothiocyanate. Different concentrations of chemically modified nanoparticles were incubated with cancer cells and confocal microscopy was performed."

According to the news editors, the research concluded: "Imaging analysis showed an efficient cellular uptake and homogeneous distribution of nanoparticles in cytoplasm and nucleus, thus suggesting their potentiality as nanocarriers for drug delivery."

For more information on this research see: Diatomite silica nanoparticles for drug delivery. Nanoscale Research Letters, 2014;9():1-7. Nanoscale Research Letters can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer -; Nanoscale Research Letters -

The news editors report that additional information may be obtained by contacting I. Ruggiero, CNR, Inst Genet & Biophys, I-80131 Naples, Italy. Additional authors for this research include M. Terracciano, N.M. Martucci, L. De Stefano, N. Migliaccio, R. Tate, I. Rendina, P. Arcari, A. Lamberti and I. Rea (see also Drugs and Therapies).

Keywords for this news article include: Italy, Naples, Europe, Nanoparticle, Nanotechnology, Drugs and Therapies, Drug Delivery Systems, Emerging Technologies

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Source: Biotech Week

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