"It almost sounds like science fiction," Canic said. "Our project combines the most recent breakthroughs in technology, such as 3-D human organ printing, materials science, mathematics, scientific computations and cardiovascular sciences."
Specifically, together with Dr.
An emerging treatment for patients with failing valves, TVR entails implanting a prosthetic valve through the skin, using catheterization to forgo more invasive surgery. Going through the groin area, a catheter containing a replacement valve is guided to the location of the failing valve. Canic says the stent holding this bioartificial valve is made of a shape memory alloy that assumes a predefined shape optimized for TVR procedures once it reaches the patient's body temperature of 98.6 degrees Fahrenheit. When the catheter reaches the location of the failing valve, the stent expands and anchors the bioartificial valve in place.
"Our computational results are being validated using functional, 3-D, patient-specific models in Dr. Little's lab. We are then testing them with virtual TVR procedures performed in an apparatus, called the pulsatile flow loop, at the Methodist DeBakey Heart and Vascular Center," Canic said. "By combining 3-D human organ printing and computational simulations of anatomic and physiologic conditions associated with TVR at this patient-specific level, the experimental and computational methods we're developing provide new information on the optimal design for this procedure."
Canic's research group at UH includes
Recognized as one of the leading experts in the world in the area of mathematical modeling and scientific computing related to cardiovascular science, Canic recently was honored at the 2014
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