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Research Data from King Abdul-Aziz University Update Understanding of Tissue Engineering (Tough and flexible CNT-polymeric hybrid scaffolds for...

August 20, 2014

Research Data from King Abdul-Aziz University Update Understanding of Tissue Engineering (Tough and flexible CNT-polymeric hybrid scaffolds for engineering cardiac constructs)

By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in Biomedicine and Biomedical Engineering. According to news reporting originating from Jeddah, Saudi Arabia, by NewsRx correspondents, research stated, "In the past few years, a considerable amount of effort has been devoted toward the development of biomimetic scaffolds for cardiac tissue engineering. However, most of the previous scaffolds have been electrically insulating or lacked the structural and mechanical robustness to engineer cardiac tissue constructs with suitable electrophysiological functions."

Our news editors obtained a quote from the research from King Abdul-Aziz University, "Here, we developed tough and flexible hybrid scaffolds with enhanced electrical properties composed of carbon nanotubes (CNTs) embedded aligned poly(-glycerol sebacate):gelatin (PG) electrospun nanofibers. Incorporation of varying concentrations of CNTs from 0 to 1.5% within the PG nanofibrous scaffolds (CNT-PG scaffolds) notably enhanced fiber alignment and improved the electrical conductivity and toughness of the scaffolds while maintaining the viability, retention, alignment, and contractile activities of cardiomyocytes (CMs) seeded on the scaffolds. The resulting CNT-PG scaffolds resulted in stronger spontaneous and synchronous beating behavior (3.5-fold lower excitation threshold and 2.8-fold higher maximum capture rate) compared to those cultured on PG scaffold. Overall, our findings demonstrated that aligned CNT-PG scaffold exhibited superior mechanical properties with enhanced CM beating properties."

According to the news editors, the research concluded: "It is envisioned that the proposed hybrid scaffolds can be useful for generating cardiac tissue constructs with improved organization and maturation."

For more information on this research see: Tough and flexible CNT-polymeric hybrid scaffolds for engineering cardiac constructs. Biomaterials, 2014;35(26):7346-7354. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier -; Biomaterials -

The news editors report that additional information may be obtained by contacting M. Kharaziha, King Abdulaziz Univ, Dept. of Phys, Jeddah 21569, Saudi Arabia. Additional authors for this research include S.R. Shin, M. Nikkhah, S.N. Topkaya, N. Masoumi, N. Annabi, M.R. Dokmeci and A. Khademhosseini (see also Biomedicine and Biomedical Engineering).

Keywords for this news article include: Asia, Tissue Engineering, Biomedicine and Biomedical Engineering, Jeddah, Cardiology, Saudi Arabia, Bioengineering

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Source: Biotech Week

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