Research Conducted at Seoul National University Has Provided New Information about Drug Delivery Systems (Electromechanical method coupling non-invasive skin impedance probing and in vivo subcutaneous liquid microinjection: controlling the ...)
By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in Drugs and Therapies. According to news reporting originating from Suwon, South Korea, by NewsRx correspondents, research stated, "Transdermal drug delivery is the way to transport drug carriers, such as nanoparticles, across the skin barrier to the dermal and/or subcutaneous layer. In order to control the transdermal drug delivery process, based on the heterogeneous and nonlinear structures of the skin tissues, we developed a novel electromechanical method combining in vivo local skin impedance probing, subcutaneous micro-injection of colloidal nanoparticles, and transcutaneous electrical stimulation."
Our news editors obtained a quote from the research from Seoul National University, "Experiments on the nude mice using in vivo fluorescence imaging exhibited significantly different apparent diffusion patterns of the nanoparticles depending on the skin impedance: Anisotropic and isotropic patterns were observed upon injection into low and high impedance points, respectively. This result implies that the physical complexity in living tissues may cause anisotropic diffusion of drug carriers, and can be used as a parameter for controlling drug delivery process."
According to the news editors, the research concluded: "This method also can be combined with microneedle-based drug release systems, micro-fabricated needle-electrodes, and/or advanced in vivo targeting/imaging technologies using nanoparticles."
For more information on this research see: Electromechanical method coupling non-invasive skin impedance probing and in vivo subcutaneous liquid microinjection: controlling the diffusion pattern of nanoparticles within living soft tissues. Biomedical Microdevices, 2014;16(4):645-653. Biomedical Microdevices can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Biomedical Microdevices - www.springerlink.com/content/1387-2176/)
The news editors report that additional information may be obtained by contacting B. Sung, Seoul National University, Adv Inst Convergence Technol, Suwon 443270, South Korea. Additional authors for this research include S.H. Kim, J.K. Lee, B.C. Lee and K.S. Soh (see also Drugs and Therapies).
Keywords for this news article include: Asia, Suwon, South Korea, Nanoparticle, Nanotechnology, Drugs and Therapies, Drug Delivery Systems, Emerging Technologies
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