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Research Conducted at Polytechnic University Has Updated Our Knowledge about Antifungals (Lipid Nanocarriers with Antifungal Activity Prepared by...

August 20, 2014



Research Conducted at Polytechnic University Has Updated Our Knowledge about Antifungals (Lipid Nanocarriers with Antifungal Activity Prepared by High Pressure Homogenization)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Drugs and Therapies. According to news originating from Bucharest, Romania, by NewsRx correspondents, research stated, "Nanostructured lipid carriers (NLC) are promising nanoparticulate delivery systems produced from blends of liquid and solid lipids. In the present paper, the influence of different synthesis parameters (e.g. pressure, homogenization cycle, surfactant and drug concentrations, lipid blends etc.) on the main particles diameters of Nystatin-loaded NLC prepared by high pressure homogenization method have been monitored by dynamic light scattering technique."

Our news journalists obtained a quote from the research from Polytechnic University, "NLC formulations were prepared using two different lipid mixtures (Emulgade, Glycerol monostearate and Savory oil) and using two surfactants systems as stabilizing agents. Dynamic light scattering measurements performed on NLC showed that the oil nanocompartments incorporated into NLC solid matrix provide a good distribution of the antifungal agent inside the nanocarrier system. The percentage of encapsulated Nystatin is influenced by the concentration of Savory oil and lipid blend. From the results obtained, the prepared lipid nanocarriers showed an increase of Nystatin entrapment for 1% loading in comparison with 0.5% loading."

According to the news editors, the research concluded: "Chemiluminescence assay proved that the protective activity against oxygen free radicals has been increased by incorporation of Savory oil into lipid nanocarriers."

For more information on this research see: Lipid Nanocarriers with Antifungal Activity Prepared by High Pressure Homogenization. Revista De Chimie, 2014;65(6):671-675. Revista De Chimie can be contacted at: Chiminform Data S A, Calea Plevnei Nr 139, Sector 6, Bucharest R-77131, Romania (see also Drugs and Therapies).

The news correspondents report that additional information may be obtained from A. Bors, Univ Politehn Bucuresti, Fac Appl Chem & Mat Sci, Bucharest 011060, Romania. Additional authors for this research include G. Niculae, R. Stan and A. Meghea.

Keywords for this news article include: Antifungals, Europe, Romania, Bucharest, Nanocarriers, Nanotechnology, Drugs and Therapies, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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