Reports from University of North Carolina Describe Recent Advances in Cisplatin Therapy (Turning a water and oil insoluble cisplatin derivative into a nanoparticle formulation for cancer therapy)
By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Drugs and Therapies are presented in a new report. According to news reporting originating from Chapel Hill, North Carolina, by NewsRx correspondents, research stated, "The formulation of water insoluble organic compounds into nanoparticles has become a widely established method for enhancing the delivery and efficacy of cancer therapeutics. Therefore, a comparable approach when applied to water insoluble inorganic compounds should also promote similar advantages."
Our news editors obtained a quote from the research from the University of North Carolina, "Herein, we have successfully formulated insoluble iodinated cisplatin (CDDP-I) into an LPI NPs (lipid-coated iodinated CDDP nanoparticles). Two separate microemulsions were combined, each containing a precursor for the synthesis of CDDP-I. The resulting CDDP-I precipitate was then coated with an anionic lipid and dispersed in water with the help of an additional lipid. This method allows us to effectively encapsulate CDDP-I and was able to achieve a considerable drug loading of 82 wt%. Administered LPI NPs demonstrated high level accumulation in tumor tissues and exhibited an anti-cancer activity comparable to free CDDP in two melanoma xenograft models without inducing nephrotoxicity."
According to the news editors, the research concluded: "The benefits offered through this delivery formulation are not unique to CDDP-I, as this versatile platform may be extended to the formulation of other inorganic compounds that are both water and oil insoluble into nanoparticles for superior anti-cancer efficacy."
For more information on this research see: Turning a water and oil insoluble cisplatin derivative into a nanoparticle formulation for cancer therapy. Biomaterials, 2014;35(26):7647-7653. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
The news editors report that additional information may be obtained by contacting S.T. Guo, University of North Carolina, Eshelman Sch Pharm, Center Nanotechnol Drug Delivery, Chapel Hill, NC 27599, United States. Additional authors for this research include Y.H. Wang, L. Miao, Z.H. Xu, C.H.M. Lin and L. Huang (see also Drugs and Therapies).
Keywords for this news article include: Antineoplastics, Pharmaceuticals, Cancer, Oncology, Cisplatin, Chapel Hill, Nanoparticle, United States, North Carolina, Nanotechnology, Alkylating Agents, Chlorine Compounds, Nitrogen Compounds, Platinum Compounds, Drugs and Therapies, Emerging Technologies, North and Central America
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