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Reports from Shandong Cancer Hospital Describe Recent Advances in Cancer Gene Therapy (Hypoxia-targeted triple suicide gene therapy radiosensitizes...

August 18, 2014



Reports from Shandong Cancer Hospital Describe Recent Advances in Cancer Gene Therapy (Hypoxia-targeted triple suicide gene therapy radiosensitizes human colorectal cancer cells)

By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Research findings on Biotechnology are discussed in a new report. According to news reporting originating in Shandong, People's Republic of China, by NewsRx journalists, research stated, "The hypoxic microenvironment, an important feature of human solid tumors but absent in normal tissue, may provide an opportunity for cancer-specific gene therapy. The purpose of the present study was to investigate whether hypoxia-driven triple suicide gene TK/CD/UPRT expression enhances cytotoxicity to ganciclovir (GCV) and 5-fluorocytosine (5-FC), and sensitizes human colorectal cancer to radiation in vitro and in vivo."

The news reporters obtained a quote from the research from Shandong Cancer Hospital, "Stable transfectant of human colorectal HCT8 cells was established which expressed hypoxia-inducible vectors (HRE-TK/eGFP and HRE-CD/UPRT/mDsRed). Hypoxia-induced expression/function of TK, CD and UPRT was verified by western blot analysis, flow cytometry, fluorescent microscopy and cytotoxicity assay of GCV and 5-FC. Significant radiosensitization effects were detected after 5-FC and GCV treatments under hypoxic conditions. In the tumor xenografts, the distribution of TK/eGFP and CD/UPRT/mDsRed expression visualized with fluorescence microscopy was co-localized with the hypoxia marker pimonidazole positive staining cells. Furthermore, administration of 5-FC and GCV in mice in combination with local irradiation resulted in tumor regression, as compared with prodrug or radiation treatments alone."

According to the news reporters, the research concluded: "Our data suggest that the hypoxia-inducible TK/GCV+CDUPRT/5-FC triple suicide gene therapy may have the ability to specifically target hypoxic cancer cells and significantly improve the tumor control in combination with radiotherapy."

For more information on this research see: Hypoxia-targeted triple suicide gene therapy radiosensitizes human colorectal cancer cells. Oncology Reports, 2014;32(2):723-729. Oncology Reports can be contacted at: Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece (see also Biotechnology).

Our news correspondents report that additional information may be obtained by contacting H.T. Hsiao, Shandong Canc Hosp & Inst, PET CT Center, Jinan 250117, Shandong, People's Republic of China. Additional authors for this research include L.G. Xing, X.L. Deng, X.R. Sun, C.C. Ling and G.C. Li.

Keywords for this news article include: Asia, Biotechnology, Shandong, Oncology, Colorectal, Colon Cancer, Bioengineering, Gastroenterology, Cancer Gene Therapy, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Gene Therapy Week


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