News Column

Patent Issued for Medical Device for Modification of Left Atrial Appendage and Related Systems and Methods

August 18, 2014



By a News Reporter-Staff News Editor at Cardiovascular Week -- Coherex Medical, Inc. (Salt Lake City, UT) has been issued patent number 8795328, according to news reporting originating out of Alexandria, Virginia, by NewsRx editors (see also Coherex Medical, Inc.).

The patent's inventors are Miles, Scott D. (Sandy, UT); Edmiston, Daryl R. (Draper, UT); Davis, Clark C. (Holladay, UT).

This patent was filed on January 8, 2010 and was published online on August 5, 2014.

From the background information supplied by the inventors, news correspondents obtained the following quote: "The atrial appendage is a feature of all human hearts. The upper chambers of the heart, the atria, have this appendage attached to each of them. The physiologic function of such appendages is not completely understood, but they do act as a filling reservoir during the normal pumping of the heart. The appendages typically protrude from the atria and cover an external portion of the atria. Atrial appendages differ substantially from one to another in size, shape and specific location with respect to the atria. For example, one atrial appendage may be configured as a tapered protrusion while another atrial appendage may be configured as a re-entrant, sock-like hole. The inner surface of an appendage is conventionally trabeculated with cords of muscular cardiac tissue traversing its surface with one or more lobes.

"The atrial appendages are inert while blood is being pumped through them during normal heart function. In other words, the appendages don't have a noticeable effect on blood pumped through them during normal heart function. However, in cases of atrial fibrillation, when the atria go into arrhythmia, blood may pool and thrombose inside of the appendages. Among other things, this can pose a stroke risk when it occurs in the left appendage since the thrombus may be pumped out of the heart and into the cranial circulation. Such can also lead to ischemic damage of other organs of the body.

"Historically, atrial appendages have sometimes been modified surgically to reduce the risk imposed by atrial fibrillation. In more recent years, devices which may be delivered percutaneously into the left atrial appendage have been introduced. The basic function of these devices is to exclude the volume within the appendage with an implant which then allows blood within the appendage to safely thrombose and then to be gradually incorporated into cardiac tissue. This can leave a smooth, endothelialized surface where the appendage used to be.

"In comparison to surgical procedures, devices implanted percutaneously are clearly a less invasive means for addressing the problems associated with the left atrial appendage. However, due to the wide variability of the size of the ostium and the volume of an atrial appendage, implant devices that are currently used typically include structure that cannot meet such variability, resulting in inadequate devices for many left atrial appendages. Further, such implant devices are substantially limited by the orientation by which they can successfully be deployed. Thus, successful placement and deployment of such devices becomes limited.

"As such, it would be advantageous to provide percutaneous systems, methods and devices that, among other things, address one or more issues such as implant orientation and the variability in sizes of the left atrial appendage in order to provide high success in left atrial appendage modification."

Supplementing the background information on this patent, NewsRx reporters also obtained the inventors' summary information for this patent: "The present invention includes various embodiments of medical devices, systems and methods for modifying an atrial appendage. In accordance with one embodiment of the present invention, a medical device is provided for modifying an atrial appendage. The medical device includes a plurality of discrete frame segments coupled with at least one ring member to form a frame structure. Each discrete frame segment includes an expanding leg, a collapsing leg and a hub extension. A tissue growth member is coupled with the plurality of discrete frame segments to define a substantially convex surface and a substantially concave surface.

"In one embodiment, the tissue growth member includes a porous foam material. The tissue growth member may further comprise expanded polytetrafluoroethylene. In one embodiment, the discrete frame segments are formed of a nickel-titanium alloy. The discrete frame segments may be formed such that each expanding leg is coplanar with its associated collapsing leg and its associated hub extension. Various other features and configurations may be associated with the medical device.

"In accordance with another embodiment of the present invention, a medical device system is provided. The system includes a medical device having a plurality of discrete frame segments coupled with at least one ring member to form a frame structure. Each discrete frame segment includes an expanding leg, a collapsing leg, and a hub extension. A tissue growth member is coupled with the plurality of discrete frame segments to define a substantially convex surface and a substantially concave surface. The system further includes a catheter and a pusher member configured to displace the medical device relative to the catheter.

"In accordance with another embodiment of the present invention, a method of forming a medical device is provided. The method includes forming a plurality of discrete frame segments, wherein each discrete frame segment includes an expanding leg, a collapsing leg, and a hub extension. The hub extension of each of the plurality of discrete frame segments is coupled with at least one ring member and a tissue growth member is coupled with the plurality of discrete frame segments."

For the URL and additional information on this patent, see: Miles, Scott D.; Edmiston, Daryl R.; Davis, Clark C.. Medical Device for Modification of Left Atrial Appendage and Related Systems and Methods. U.S. Patent Number 8795328, filed January 8, 2010, and published online on August 5, 2014. Patent URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8795328.PN.&OS=PN/8795328RS=PN/8795328

Keywords for this news article include: Cardiology.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cardiovascular Week


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