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New Nanoparticles Findings from Chinese Academy of Science Discussed (Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective...

August 22, 2014



New Nanoparticles Findings from Chinese Academy of Science Discussed (Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation)

By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on Nanoparticles is now available. According to news reporting out of Shanghai, People's Republic of China, by NewsRx editors, research stated, "Hypoxia is a distinct feature of malignant solid tumors, which is a possible causative factor for the serious resistance to chemo- and radiotherapy or the development of invasion and metastasis. The exploration of nanosensors with the capabilities like the accurate diagnosis of hypoxic level will be helpful to estimate the malignant degree of tumor and subsequently implement more effective personalized treatment."

Our news journalists obtained a quote from the research from the Chinese Academy of Science, "Here, we report the design and synthesis of nanosensors that can selectively and reversibly detect the level of hypoxia both in vitro and in vivo. The designed nanosensor is composed of two main moieties: oxygen indicator [Ru(dpp)(3)]Cl-2+(2) or detection of hypoxia and upconversion nanoparticles for offering the excitation light of [Ru(dpp)(3)]Cl-2+(2) by upconversion process under 980 nm exposure. The results show that the nanosensors can reversibly become quenched or luminescent under hyperoxic or hypoxic conditions, respectively. Compared with free [Ru(dpp)(3)]Cl-2+(2), the designed nanosensors exhibit enhanced sensitivity for the detection of oxygen in hypoxic regions. More attractively, the nanosensors can image hypoxic regions with high penetration depth because the absorption and emission wavelength are within the NIR and far-red region, respectively."

According to the news editors, the research concluded: "Most importantly, nanosensors display a high selectivity for detection of relevant oxygen changes in cells and zebrafish."

For more information on this research see: Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation. Journal of the American Chemical Society, 2014;136(27):9701-9709. Journal of the American Chemical Society can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of the American Chemical Society - www.pubs.acs.org/journal/jacsat)

Our news journalists report that additional information may be obtained by contacting J.N. Liu, Chinese Academy Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Shanghai 200031, People's Republic of China. Additional authors for this research include Y. Liu, W.B. Bu, J.W. Bu, Y. Sun, J.L. Du and J.L. Shi (see also Nanoparticles).

Keywords for this news article include: Asia, Shanghai, Nanotechnology, Emerging Technologies, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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