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New Mononuclear Phagocyte System Findings Has Been Reported by Investigators at National Center for Nanoscience and Technology (In vitro enhancement...

August 20, 2014



New Mononuclear Phagocyte System Findings Has Been Reported by Investigators at National Center for Nanoscience and Technology (In vitro enhancement of dendritic cell-mediated anti-glioma immune response by graphene oxide)

By a News Reporter-Staff News Editor at Biotech Week -- New research on Immunology is the subject of a report. According to news originating from Beijing, People's Republic of China, by NewsRx correspondents, research stated, "Malignant glioma has extremely poor prognosis despite combination treatments with surgery, radiation, and chemotherapy. Dendritic cell (DC)-based immunotherapy may potentially serve as an adjuvant treatment of glioma, but its efficacy generally needs further improvement."

Our news journalists obtained a quote from the research from National Center for Nanoscience and Technology, "Here we explored whether graphene oxide (GO) nanosheets could modulate the DC-mediated anti-glioma immune response in vitro, using the T98G human glioma cell line as the study model. Pulsing DCs with a glioma peptide antigen (Ag) generated a limited anti-glioma response compared to un-pulsed DCs. Pulsing DCs with GO alone failed to produce obvious immune modulation effects. However, stimulating DCs with a mixture of GO and Ag (GO-Ag) significantly enhanced the anti-glioma immune reaction (p < 0.05). The secretion of interferon gamma (IFN-gamma) by the lymphocytes was also markedly boosted by GO-Ag. Additionally, the anti-glioma immune response induced by GO-Ag appeared to be target-specific. Furthermore, at the concentration used in this study, GO exhibited a negligible effect on the viability of the DCs."

According to the news editors, the research concluded: "These results suggested that GO might have potential utility for boosting a DC-mediated anti-glioma immune response."

For more information on this research see: In vitro enhancement of dendritic cell-mediated anti-glioma immune response by graphene oxide. Nanoscale Research Letters, 2014;9():1-9. Nanoscale Research Letters can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Nanoscale Research Letters - www.springerlink.com/content/1931-7573/)

The news correspondents report that additional information may be obtained from W. Wang, Natl Center Nanosci & Technol, Beijing 100190, People's Republic of China. Additional authors for this research include Z.J. Li, J.H. Duan, C. Wang, Y. Fang and X.D. Yang (see also Immunology).

Keywords for this news article include: Asia, Antigen-Presenting Cells, Beijing, Immunology, Dendritic Cells, People's Republic of China, Mononuclear Phagocyte System

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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