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New Malaria Findings from University of Zaragoza Discussed (Amphiphilic dendritic derivatives as nanocarriers for the targeted delivery of...

August 20, 2014



New Malaria Findings from University of Zaragoza Discussed (Amphiphilic dendritic derivatives as nanocarriers for the targeted delivery of antimalarial drugs)

By a News Reporter-Staff News Editor at Biotech Week -- New research on Mosquito-Borne Diseases is the subject of a report. According to news originating from Zaragoza, Spain, by NewsRx correspondents, research stated, "It can be foreseen that in a future scenario of malaria eradication, a varied armamentarium will be required, including strategies for the targeted administration of antimalarial compounds. The development of nanovectors capable of encapsulating drugs and of delivering them to Plasmodium-infected cells with high specificity and efficacy and at an affordable cost is of particular interest."

Our news journalists obtained a quote from the research from the University of Zaragoza, "With this objective, dendritic derivatives based on 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) and Pluronic polymers have been herein explored. Four different dendritic derivatives have been tested for their capacity to encapsulate the antimalarial drugs chloroquine (CQ) and primaquine (PQ), their specific targeting to Plasmodium-infected red blood cells (pRBCs), and their antimalarial activity in vitro against the human pathogen Plasmodium falciparum and in vivo against the rodent malaria species Plasmodium yoelii. The results obtained have allowed the identification of two dendritic derivatives exhibiting specific targeting to pRBCs vs. non-infected RBCs, which reduce the in vitro IC50 of CQ and PQ by ca. 3- and 4-fold down to 4.0 nm and 1.1 mu m, respectively."

According to the news editors, the research concluded: "This work on the application of dendritic derivatives to antimalarial targeted drug delivery opens the way for the use of this new type of chemicals in future malaria eradication programs."

For more information on this research see: Amphiphilic dendritic derivatives as nanocarriers for the targeted delivery of antimalarial drugs. Biomaterials, 2014;35(27):7940-7950. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)

The news correspondents report that additional information may be obtained from J. Movellan, University of Zaragoza, CSIC, Inst Ciencia Mat Aragon, ES-50009 Zaragoza, Spain. Additional authors for this research include P. Urban, E. Moles, J.M. de la Fuente, T. Sierra, J.L. Serrano and X. Fernandez-Busquets (see also Mosquito-Borne Diseases).

Keywords for this news article include: Antiinfectives, Antimalarial Agents, Antiprotozoal Agents, Spain, Europe, Therapy, Zaragoza, Nanocarriers, Nanotechnology, Protozoan Infections, Emerging Technologies, Mosquito-Borne Diseases

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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