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New Life Science Research Study Findings Have Been Reported by Researchers at Princeton University [Spatial covariance reconstructive (SCORE)...

August 19, 2014

New Life Science Research Study Findings Have Been Reported by Researchers at Princeton University [Spatial covariance reconstructive (SCORE) super-resolution fluorescence microscopy]

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Life Science Research. According to news reporting from Princeton, New Jersey, by NewsRx journalists, research stated, "Super-resolution fluorescence microscopy has become a powerful tool to resolve structural information that is not accessible to traditional diffraction-limited imaging techniques such as confocal microscopy. Stochastic optical reconstruction microscopy (STORM) and photoactivation localization microscopy (PALM) are promising super-resolution techniques due to their relative ease of implementation and instrumentation on standard microscopes."

The news correspondents obtained a quote from the research from Princeton University, "However, the application of STORM is critically limited by its long sampling time. Several recent works have been focused on improving the STORM imaging speed by making use of the information from emitters with overlapping point spread functions (PSF). In this work, we present a fast and efficient algorithm that takes into account the blinking statistics of independent fluorescence emitters. We achieve sub-diffraction lateral resolution of 100 nm from 5 to 7 seconds of imaging."

According to the news reporters, the research concluded: "Our method is insensitive to background and can be applied to different types of fluorescence sources, including but not limited to the organic dyes and quantum dots that we demonstrate in this work."

For more information on this research see: Spatial covariance reconstructive (SCORE) super-resolution fluorescence microscopy. Plos One, 2014;9(4):e94807. (Public Library of Science -; Plos One -

Our news journalists report that additional information may be obtained by contacting Y. Deng, Dept. of Physics, Princeton University, Princeton, New Jersey, United States. Additional authors for this research include M. Sun, P.H. Lin, J. Ma and J.W Shaevitz (see also Life Science Research).

Keywords for this news article include: Princeton, New Jersey, United States, Life Science Research, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Life Science Weekly

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