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New Industrial Biotechnology Study Findings Have Been Reported by Researchers at Shanghai University (Integrated strategy of pH-shift and glucose...

August 20, 2014



New Industrial Biotechnology Study Findings Have Been Reported by Researchers at Shanghai University (Integrated strategy of pH-shift and glucose feeding for enhanced production of bioactive Antrodin C in submerged fermentation of Antrodia ...)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Biotechnology. According to news originating from Shanghai, People's Republic of China, by NewsRx correspondents, research stated, "Antrodin C is one of the most potent bioactive components produced by the medicinal mushroom Antrodia camphorata. However, almost all studies in this field have focused on the biological activity of Antrodin C and relatively rare information has been reported regarding the biosynthetic process of Antrodin C. In this study, the strategies of pH-shift and glucose feeding for enhanced production of Antrodin C in submerged fermentation of A. camphorata were successfully applied in stirred bioreactors."

Our news journalists obtained a quote from the research from Shanghai University, "The critical parameters for pH-shift and glucose feeding were systematically investigated. On one hand, the optimal culture pH for cell growth was distinct with Antrodin C biosynthesis and the maximum Antrodin C production was obtained by maintaining the first-stage culture at initial pH 4.5 and adjusted to 6.0 at day 8. On the other hand, it was beneficial for the Antrodin C accumulation with the initial glucose concentration of 40 g/L and feeding glucose to keep the residual sugar above 10 g/L. The maximum Antrodin C production (1,549.06 mg/L) was about 2.1-fold higher than that of control in 15-L stirred bioreactors by taking advantage of the integrated strategy of pH-shift and glucose feeding."

According to the news editors, the research concluded: "These results would be helpful for the design of a highly efficient Antrodin C biosynthesis process."

For more information on this research see: Integrated strategy of pH-shift and glucose feeding for enhanced production of bioactive Antrodin C in submerged fermentation of Antrodia camphorata. Journal of Industrial Microbiology & Biotechnology, 2014;41(8):1305-1310. Journal of Industrial Microbiology & Biotechnology can be contacted at: Springer Heidelberg, Tiergartenstrasse 17, D-69121 Heidelberg, Germany. (Springer - www.springer.com; Journal of Industrial Microbiology & Biotechnology - www.springerlink.com/content/1367-5435/)

The news correspondents report that additional information may be obtained from H. Zhang, Shanghai Univ Sci & Technol, Sch Med Instrument & Food Engn, Shanghai 200093, People's Republic of China. Additional authors for this research include Y.D. Hu, R.Q. Lu, Y.J. Xia, B.B. Zhang and G.R. Xu (see also Biotechnology).

Keywords for this news article include: Asia, Biotechnology, Shanghai, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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