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New Gene Therapy Data Have Been Reported by M.G. Notarangelo and Co-Authors (Gene therapy: the role of cytoskeleton in gene transfer studies based on...

August 21, 2014



New Gene Therapy Data Have Been Reported by M.G. Notarangelo and Co-Authors (Gene therapy: the role of cytoskeleton in gene transfer studies based on biology and mathematics)

By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Researchers detail new data in Biotechnology. According to news reporting from Rome, Italy, by NewsRx journalists, research stated, "Gene therapy is a promising approach for treating a wide range of human pathologies such as genetic disorders as well as diseases acquired over time. Viral and non-viral vectors are used to convey sequences of genes that can be expressed for therapeutic purposes."

The news correspondents obtained a quote from the research, "Plasmid DNA is receiving considerable attention for intramuscular gene transfer due to its safety, simplicity and low cost of production. Nevertheless, strategies to improve DNA uptake into the nucleus of cells for its expression are required. Cytoskeleton plays an important role in the intracellular trafficking. The mechanism regulating this process must be elucidated. Here, we propose a new methodological approach based on the coupling of biology assays and predictive mathematical models, in order to clarify the mechanism of the DNA uptake and its expression into the cells."

According to the news reporters, the research concluded: "Once these processes are better clarified, we will be able to propose more efficient therapeutic gene transfer protocols for the treatment of human patients."

For more information on this research see: Gene therapy: the role of cytoskeleton in gene transfer studies based on biology and mathematics. Current Gene Therapy, 2014;14(2):121-7. (Bentham Science Publishers - www.benthamscience.com; Current Gene Therapy - www.benthamscience.com/cgt/index.htm)

Our news journalists report that additional information may be obtained by contacting M.G. Notarangelo, Laboratory of Molecular Pathology and Experimental Oncology, CNR-IFT, via Fosso del Cavaliere 100, 00133, Rome, Italy. Additional authors for this research include R. Natalini and E. Signori (see also Biotechnology).

Keywords for this news article include: Rome, Biotechnology, Italy, Europe, Cytoskeleton, Gene Therapy, Bioengineering, Cellular Structures, Intracellular Space, Cytoplasmic Structures.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Gene Therapy Weekly


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