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New Findings from Qingdao Institute of Bioenergy and Bioprocess Technology Yields New Data on Biotechnology (De-novo synthesis of 2-phenylethanol by...

August 20, 2014



New Findings from Qingdao Institute of Bioenergy and Bioprocess Technology Yields New Data on Biotechnology (De-novo synthesis of 2-phenylethanol by Enterobacter sp. CGMCC 5087)

By a News Reporter-Staff News Editor at Biotech Week -- A new study on Technology is now available. According to news originating from Qingdao, People's Republic of China, by NewsRx correspondents, research stated, "2-phenylethanl (2-PE) and its derivatives are important chemicals, which are widely used in food materials and fine chemical industries and polymers and it's also a potentially valuable alcohol for next-generation biofuel. However, the biosynthesis of 2-PE are mainly biotransformed from phenylalanine, the price of which barred the production."

Our news journalists obtained a quote from the research from the Qingdao Institute of Bioenergy and Bioprocess Technology, "Therefore, it is necessary to seek more sustainable technologies for 2-PE production. A new strain which produces 2-PE through the phenylpyruvate pathway was isolated and identified as Enterobacter sp. CGMCC 5087. The strain is able to use renewable monosaccharide as the carbon source and NH4Cl as the nitrogen source to produce 2-PE. Two genes of rate-limiting enzymes, chorismate mutase p-prephenate dehydratase (PheA) and 3-deoxy-d-arabino-heptulosonic acid 7-phosphate synthase (DAHP), were cloned from Escherichia coli and overexpressed in E. sp. CGMCC 5087. The engineered E. sp. CGMCC 5087 produces 334.9 mg L? 2-PE in 12 h, which is 3.26 times as high as the wild strain. The phenylpyruvate pathway and the substrate specificity of 2-keto-acid decarboxylase towards phenylpyruvate were found in E. sp. CGMCC 5087."

According to the news editors, the research concluded: "Combined with the low-cost monosaccharide as the substrate, the finding provides a novel and potential way for 2-PE production."

For more information on this research see: De-novo synthesis of 2-phenylethanol by Enterobacter sp. CGMCC 5087. Bmc Biotechnology, 2014;14():30. (BioMed Central - www.biomedcentral.com/; Bmc Biotechnology - www.biomedcentral.com/bmcbiotechnol/)

The news correspondents report that additional information may be obtained from H. Zhang, CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No189 Songling Road, Laoshan District, Qingdao, PR 266101, People's Republic of China. Additional authors for this research include M. Cao, X. Jiang, H. Zou, C. Wang, X. Xu and M. Xian (see also Technology).

Keywords for this news article include: Asia, Qingdao, Technology, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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