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New Drug Delivery Systems Data Have Been Reported by Investigators at University of Florida (Enzyme-Responsive Hydrogel Microparticles for Pulmonary...

August 20, 2014



New Drug Delivery Systems Data Have Been Reported by Investigators at University of Florida (Enzyme-Responsive Hydrogel Microparticles for Pulmonary Drug Delivery)

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Drugs and Therapies have been published. According to news reporting from Gainesville, Florida, by NewsRx journalists, research stated, "Poly(ethylene glycol) based hydrogel microparticles were developed for pulmonary drug delivery. Hydrogels are particularly attractive for pulmonary delivery because they can be size engineered for delivery into the bronchi, yet also swell upon reaching their destination to avoid uptake and clearance by alveolar macrophages."

The news correspondents obtained a quote from the research from the University of Florida, "To develop enzyme-responsive hydrogel microparticles for pulmonary delivery a new synthesis method based on a solution polymerization was developed. This method produces spherical poly(ethylene glycol) (PEG) microparticles from high molecular weight poly(ethylene glycol) diacrylate (PEGDA)-based precursors that incorporate peptides in the polymer chain. Specifically, we have synthesized hydrogel microparticles that degrade in response to matrix metalloproteinases that are overexpressed in pulmonary diseases. Small hydrogel microparticles with sizes suitable for lung delivery by inhalation were obtained from solid precursors when PEGDA was dissolved in water at a high concentration. The average diameter of the particles was between 2.8 and 4 mu m, depending on the molecular weight of the precursor polymer used and its concentration in water."

According to the news reporters, the research concluded: "The relation between the physical properties of the particles and their enzymatic degradation is also reported, where an increased mesh size corresponds to increased degradation."

For more information on this research see: Enzyme-Responsive Hydrogel Microparticles for Pulmonary Drug Delivery. ACS Applied Materials & Interfaces, 2014;6(13):10313-10321. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)

Our news journalists report that additional information may be obtained by contacting E. Secret, University of Florida, Dept. of Mat Sci & Engn, Gainesville, FL 32611, United States. Additional authors for this research include S.J. Kelly, K.E. Crannell and J.S. Andrew (see also Drugs and Therapies).

Keywords for this news article include: Florida, Alcohols, Hydrogel, Gainesville, United States, Organic Chemicals, Drugs and Therapies, Polyethylene Glycols, Drug Delivery Systems, Enzymes and Coenzymes, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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